December 29, 2016

Core & Project Leads

William T. Dauer, MD

William T. Dauer, MD
Director, U-M Udall Center

Udall Administrative Core Lead
Udall Project 3 Co-Lead
Elinor Levine Professor of Neurology
Director, U-M Movement Disorders Group
Associate Professor of Cell and Molecular Biology

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William T. Dauer, MD is the Elinor Levine Professor of Neurology, Director of the U-M Movement Disorders Group and Associate Professor of Cell and Molecular Biology at the University of Michigan Medical School. Dr. Dauer was Director of the Resident/Fellow Movement Disorders Clinic at Columbia University Medical Center from 2002 - 2009. His laboratory is widely known for its seminal contributions to the molecular pathogenesis of PD and dystonia, using cell and animal models to elucidate the roles of α- synuclein, LRRK2 and torsinA in these diseases. Several of his clinical trainees are now successful clinicians and academicians and two of his laboratory trainees hold academic faculty positions and are laboratory PIs.

His accomplishments have been recognized by several distinctions, including election to the American Neurological Association and the American Society for Clinical Investigation; the Fahn Award for excellence in dystonia research and Columbia University’s Harold and Golden Lamport Award for excellence in clinical science research; acting Chair of an NIH study section (CDIN) and frequent member of the Special Emphasis Panel that reviews Udall Centers; external reviewer for the Michigan State University and Pacific Northwest Udall Centers. He was recruited to U-M in 2009 to direct and enhance the Movement Disorder Group, and the establishment of a U-M Udall Center is the centerpiece of those efforts.

Roger L. Albin, MD


Roger L Albin, MD

Associate Director, U-M Udall Center
Udall Project 3 Co-Lead
Anne B. Young Collegiate Professor
Vice Chair for Research, Department of Neurology
Chief of Neuroscience Research, VAAAHS Geriatric Research, Education and Clinical Center

Roger Albin, M.D. is the Anne B. Young Collegiate Professor and Vice Chair for Research in the Dept. of Neurology at the University of Michigan. He is also the Chief of Neuroscience Research in the Veteran’s Affairs Ann Arbor Health System’s Geriatric Research, Education and Clinical Center. Dr. Albin trained in Neurology at Michigan where he subsequently pursued a combined clinical and research fellowship under the mentorship of Anne Young and the late Jack Penney. He is internationally recognized as a leader in understanding the pathophysiology and pathogenesis of basal ganglia diseases, particularly in understanding the neurochemical-anatomic correlates of clinical features of basal ganglia disorders. With Drs. Penney and Young, he developed the “classic model” of basal ganglia pathophysiology, which continues to be influential and in part established the rationale for target selection for surgical treatments for Parkinson disease. That work and his subsequent laboratory studies, predominantly in rodent models of Parkinson and Huntington disease, have yielded fundamental insights into the anatomy, physiology and pharmacology of these disorders.

He has long complemented this work with clinical research, predominantly using PET and related methods to define the alterations of neurochemical anatomy that underlie clinical features of basal ganglia diseases. This work includes the development and evaluation of novel PET ligands and experience with early and later phase trials in PD and Huntington disease (including serving on the DSMBs of major trials). In recent years he has focused on the very disabling non-dopaminergic features of PD, including impairments of gait and posture and abnormalities of sleep, cognition and behavior. This work, in collaboration with Dr. Nicolaas Bohnen, is the source of several key pieces of preliminary data supporting this proposal. Dr. Albin also has a long and distinguished record of mentoring and five of his trainees currently hold academic faculty positions.

Nicolaas Bohnen MD, PhD

Nicolaas Bohnen MD, PhD
Udall Clinical Core Co-Lead
Udall Project 2 Lead
Professor, Department of Radiology
Professor, Neurology

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Nico Bohnen MD, PhD is a Professor of Radiology and Neurology at the University of Michigan. He is the Director of the University of Neurology Functional Neuroimaging, Cognitive and Mobility Laboratory. His clinical research focuses on neurobiological correlates of mobility and cognition in normal aging and Parkinson disease and biomarker development for the diagnosis and treatment monitoring in Parkinson disease. He also directs the Ann Arbor VA Movement Disorders clinic where he trains Neurology residents.

Martijn Müller, PhD

Martjin Müller, PhD
Udall Clinical Core Co-Lead
Research Assistant Professor
Department of Radiology

Cathie Spino, ScD

Cathie Spino, ScD
Udall Biostatistics and Data Management Core Co-Lead
Research Associate Professor of Biostatistics
Director of Statistical Analysis of Biomedical and Educational Research (SABER)

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Cathie Spino, ScD is an Associate Research Professor in the Department of Biostatistics at U-M. She directs the Statistical Analysis of Biomedical and Educational Research (SABER) group and also serves as a faculty member for the Clinical Research Design and Statistical Analysis (CRDSA) MS program that helps physicians and health professionals develop expertise in research design and statistical analysis while continuing their professional employment. Her work through SABER involves statistical management of multicenter clinical studies -- both randomized clinical trials and other observational clinical studies. Prior to her recruitment to U-M in 2007, she worked in industry as a statistician and statistical manager in drug development programs in several therapeutic areas.

Ivo D. Dinov, PhD


Ivo D. Dinov, PhD
Udall Biostatistics and Data Management Core Co-Lead
Associate Professor
Associate Director for Education and Training, Michigan Institute for Data Science
Director, Statistics Online Computational Resource
Department of Health Behavior and Biological Sciences
School of Nursing

Ivo Dinov, PhD is an Associate Professor of Leadership and Effectiveness Science, U-M School of Nursing, and Director of the Statistics Online Computational Resource (www.SOCR.umich.edu). Before joining U-M in Fall of 2013, Dr. Dinov was an associate professor of Statistics and Neurology at UCLA, Chief Operations Officer of the Center for Computational Biology (CCB) at UCLA, and a faculty member of the Laboratory of Neuro Imaging (LONI), a leading effort in the acquisition, analysis and interpretation of neuroimaging in neurodegenerative disease. The science technology engineering and mathematics (STEM) resources developed by Dr. Dinov have been used by over 7 million users since 2002. The SOCR group led by Dr. Dinov has developed a suite of portable, platform-agnostic and integrated resources for STEM education including electronic books, learning modules, instructional materials, computational libraries, pipeline provenance workflows and web-applications. Four of his trainees are now faculty members.

Kelvin Chou, MD

Kelvin Chou, MD
Udall Education and Outreach Core Lead
Thomas H. and Susan  C. Brown Early Career Professor of Neurology
Clinical Professor, Neurology
Clinical Professor, Neurosurgery
Co-Director, Surgical Therapies Improving Movement (STIM) Program
Co-Director, Movement Disorders Clinic

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Kelvin L. Chou, MD is the Thomas H. and Susan C. Brown Professor in the Department of Neurology. Dr. Chou also serves as Co-Director of the Surgical Therapies Improving Movement (STIM) Program and Co-Director of the Movement Disorders Clinic. He has been the Director of the U-M Movement Disorders CME since its inception and serves on the CME Committee of the Movement Disorders Society. Dr. Chou sees patients with all movement disorders, but has a particular interest in Parkinson's disease (PD) and deep brain stimulation (DBS). Dr. Chou is an outstanding clinical mentor who is frequently sought out for advice and counsel regarding the diagnosis and management of patients with Movement Disorders as well as for career advice for those interested in pursuing a career in Movement Disorders.

Dr. Chou has been named to the Best Doctors of America list and sees all patients with movement disorders (i.e., Parkinson disease, tremors, dystonia, Huntington's Disease). He has particular interest in Parkinson disease (PD) and deep brain stimulation (DBS) for movement disorders, and he also has clinical expertise in botulinum toxin injections for movement disorders such as dystonia. A strong patient advocate, Dr. Chou serves on the Professional Advisory Board of the Michigan Parkinson Foundation, the Medical Advisory Board of the International Essential Tremor Foundation (IETF) and has recently published a book for patients and families called Deep Brain Stimulation: A New Life for People with Parkinson's, Dystonia and Essential Tremor.

Martin Sarter, PhD

Martin Sarter, PhD
Udall Project 1 Lead
Charles M. Butter Collegiate Professor of Psychology
Biopsychology Chair
Professor, Neuroscience

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Martin Sarter, PhD is a Professor of Psychology in the Department of Psychology at U-M. His research program is focused on understanding the basal forebrain cholinergic system and its role in cognitive functions, particularly attention. Much of this work has been conducted in rats, but his laboratory has used a wide range approaches ranging from mouse molecular work on choline transporters to human behavioral genetics and neuroimaging. He has successfully trained many graduate students and postdocs in the context of a highly productive research program (see work in Neuron, 2007; Journal of Neuroscience 2008, 2010, 2011, 2012, 2014). The U-M Udall Center is especially fortunate to have Dr. Sarter as he is new to the PD field, and he is an outstanding mentor.