November 30, 2016 Thomas Lee

Research

  • Udall Center Theme: Degeneration of brain cholinergic pathways produces cognitive deficits which disrupt integration of cognitive, sensory, and motor functions critical for normal gait and balance

    Attentional-Motor Interface

    The central theme of the University of Michigan Udall Center is the role of cholinergic deficits in treatment-refractory aspects of Parkinson disease (PD), particularly gait and balance disorders, and cognitive decline. Through an interrelated and complementary set of neuroimaging and behavioral studies in patients with PD and unique animal model experiments, Center investigators examine the contribution of distinct cholinergic projection system deficits to abnormalities of gait, balance, and cognition in PD.  A major aspect of this central theme is the role of cholinergic systems in integrating afferent sensory, attentional, and cognitive information with motor functions.

    Multiple neurochemical systems degenerate in Parkinson’s Disease (PD). Progressive gait and balance difficulties, with associated falls, are among the most common levodopa resistant symptoms, eventually occurring in nearly all patients. The consequences of these levodopa resistant symptoms are devastating, and include bone fractures, hospitalizations, self-imposed isolation because of fear of falling, wheelchair confinement, and eventual nursing home placement.  Similarly, cognitive decline is a prominent, common, and disabling feature of advancing PD, overlapping significantly with gait and balance disorders.

    Data collected by Center investigators indicates that gait and postural control are not purely “motor” functions but require complex integration of motor, sensory, and cognitive functions. Defining the relationship between cholinergic dysfunction, gait abnormalities, and cognitive decline requires a multidisciplinary approach in which investigators view the relationship between cholinergic function, gait, and cognition through different lenses, share insights and challenge each other in ways that yield progress far beyond that achievable were each project pursued separately. The research team at the Center developed data that led to the development of a conceptual model of cognitive-motor integration (the Attentional-Motor Interface above) in which cholinergic systems’ interactions with basal ganglia and cortical circuits are critical for normal function. This model provides a systems-level framework for understanding the interactive nature of gait, balance, and cognitive dysfunctions in PD and focuses experimental attention on critical nodes of this system.

    The lack of effective therapies for gait, balance, and cognitive abnormalities in advancing PD stems in large part from a limited understanding of the role of non-dopaminergic systems in the pathophysiology of these symptoms. It is increasingly clear that normal gait and balance depends upon complex interplay of motor, sensory and cognitive functions, indicating that the full spectrum of PD neuropathology must be considered to identify the responsible neural substrates. The molecular imaging work of Udall Center investigators demonstrated that PD subjects with a history of falls and/or gait freezing have differing deficits of specific cholinergic systems.  Parallel work with a unique animal model demonstrated the critical role of cholinergic systems subserving attentional functions in normal gait and balance functions.  In recent preliminary work, Udall Center molecular imaging data shows that other cholinergic deficits are related to other important aspects of motor and cognitive functions.  Complementary experimental animal model work is illuminating the specific cellular mechanisms by which the cholinergic systems and nodes identified as abnormal by Udall Center clinical research integrate diverse circuits to produce normal cognitive and motor functions. All of this work is a necessary prelude to developing interventions for these treatment refractory aspects of PD.

    Project I: Evolution of cholinergic deficits within multisensory, cognitive, and motor integration brain regions and development of PIGD features in PwP (Project Lead: Bohnen):

    Postural instability and gait difficulty (PIGD) motor features are common in Parkinson disease (PD), and a significant cause of treatment-refractory disability. Accumulating evidence implicates cholinergic systems dysfunctions as significant contributors to gait and balance impairment. During the initial funding period, we established the vesicular acetylcholine transporter (VAChT) ligand [18F]FEOBV, which uniquely assesses cholinergic terminal density in high density regions such as the striatum. Our recent cross-sectional findings suggest that PwP participants with isolated falls and those with freezing of gait (FoG) status share common cholinergic deficits in the thalamus (lateral geniculate nucleus [LGN]) and striatum (caudate) with more extensive striatal, limbic, and prefrontal VAChT reductions in PwP with FoG. Consistent with Project II preclinical data indicating a critical role for striatal cholinergic interneurons (SChI) in integration of attentional and motor functions, these data suggest that SChI deficits are a common denominator in the etiology of falls and FoG. These results emphasize the need to understand PIGD, falls, and FoG as products of cholinergic projection dysfunctions within the framework of failing Attentional-Motor Integration (AMI) combined with failures of additional multisensory and cognitive integration.

    Episodic mobility disturbances (falls, FoG) are typically preceded by insidiously developing non-episodic PIGD features. We have novel preliminary data that cholinergic deficits of the medial geniculate nucleus (MGN) and the entorhinal cortex (ERC) are robustly associated with non-episodic PIGD deficits, These results imply a significant role of impaired sensorimotor integration underlying non-episodic PIGD motor features in PwP. The overarching goal of this project is to investigate the evolution of cholinergic deficits within multisensory, cognitive and motor integration brain regions and development of PIGD features in PwP. We hypothesize that this progresses from the MGN and ERC, then LGN and caudate nucleus, and then more diffuse striatal, limbic and cortical (prefrontal followed by anterior cingulum and insula) cholinergic deficits. To assess our hypotheses, we propose to perform a prospective cohort study with [18F]FEOBV brain PET at baseline and 2-year follow-up in PD subjects at risk of conversion to non-episodic and episodic (falls and FoG) PIGD motor features. Novel insights in cholinergic changes underlying incident development of PIGD may inform new therapeutic interventions to treat these debilitating motor complications. Project I is highly integrated thematically with Project II and the Catalyst Research Project, complementary to Project III, and will interact extensively with all Cores. Our work is based on a unique, deeply phenotyped cohort of PD participants developed in the prior funding cycle allowing us to recruit an enriched sample of patients likely to convert to fall and FoG status, allowing longitudinal within-subject assessments.

    Project II: Circuit Mechanisms of Attentional-Motor Interface Dysfunction in PD Falls (Project Lead: Berridge):

    This project builds on Dr. Martin Sarter’s published and preliminary work dissecting the mechanisms of the detection of relevant cues, transfer of this information to striatum, and its integration with ongoing motor processing. Based on the Sarter team’s demonstration of a role for basal forebrain cholinergic projections in the DL (dual lesion) rodent model of PD falling, this project uses optogenetic techniques to test the hypothesis that an enhanced fall propensity can be caused specifically by the loss of fast cholinergic signaling (i.e., “transients”) known to mediate attention. Additional experiments define how cholinergic-mediated cortical attentional information is integrated with motor selection processes. Frontostriatal circuitry (glutamatergic corticostriatal projections) is essential for action planning, particularly when habit-guided action is disrupted and task shifts are needed. Such adjustment depends critically on corticostriatal information transfer to guide adaptive movement selection and sequencing. Deficient cortical cholinergic activity impairs attentional shifts toward alternative actions, uncoupling striatal action selection from goals, causing ill-timed or absent responses. Guided by this framework, intrinsic to the AMI model, Dr. Sarter’s team acquired compelling preliminary data detecting the signals encoding attentional information transferred to the striatum (via corticostriatal terminals), where it is hypothesized to be integrated with vigor and kinematic signals supplied by nigrostriatal dopaminergic terminals. Utilizing a novel behavioral paradigm, they demonstrate that a cue instructing the animal to turn evokes a time-locked increase of striatal glutamate (that will be shown to originate from corticostriatal afferents), and a similarly timed burst of acetylcholine from cholinergic neurons. Dr. Sarter’s former team, now under the direction of Dr. Berridge, is specifically testing the hypothesis that this integrative function is essential for complex motor control, including PD gait dysfunction. Preliminary findings strongly support a role for cholinergic signals in integrating the attentional and motor signals during gait; chemogenetic activation of these neurons reduces fall propensity in DL rats (often preceded by freezing-like motor behaviors in the animals), whereas their inhibition in intact animals mimics DL-type falls. These data support key aspects of the AMI model by implicating cholinergic neurotransmission at two successive nodes along the cortico-striatal pathway critical to support the attentional-motor interface – in cortex for signal detection, and in striatum for signal integration. These studies will identify key substrates of attentional-motor integration in the AMI.

    Project III: Cingulo-Opercular Task Control Network Cholinergic Dysfunction in PD (Project Lead: Albin):

     Cognitive deficits are a morbid dopamine replacement therapy-refractory feature of Parkinson disease (PD). The pathophysiology of PD-related cognitive deficits is complex, likely involving interacting and variable impairments of several brain systems, particularly in early to moderate disease. Incidence and natural history of PD cognitive deficits is heterogeneous. Understanding the pathophysiologies of PD cognitive impairments is essential for development of personalized therapies. PD heterogeneity is a major obstacle to effective clinical research. Identifying PD subgroups will enhance discovery of useful interventions through subgroup specific or stratified clinical trials, identify biomarkers, improve prognosis assessment in clinical care, and assist etiopathogenic research. Some of the “highest priority recommendations” of the NINDS PD 2014 Research Report call for research to understand the pathophysiology of cognitive impairments and for PD subgroup identification. The U-M Udall Center established a deeply phenotyped PD cohort imaged with the vesicular acetylcholine transporter PET ligand [18F]FEOBV, revealing heterogeneous cholinergic deficits. Cholinergic terminal deficits in Cingulo-Opercular Task Control network (COTC) nodes – Anterior Cingulate and Insular Cortices (AC-I) – correlate with both domain specific and global cognitive deficits. An important component of the Attentional-Motor Interface, the COTC subserves tonic attention, coordinating network activities across different cognitive domains. Preliminary analysis suggests that early COTC node (AC-I) cholinergic deficits are a subgroup defining-feature in PD, predicting more rapid cognitive decline. The central hypothesis of Project III is that early COTC node (AC-I) cholinergic denervation contributes significantly to cognitive impairment in early to moderate PD and identifies a D subgroup with accelerated cognitive decline In addition to our established Udall subject cohort, we have access to a separate cohort of incident PD subjects through collaboration with the University of Groningen, deeply phenotyped and imaged with [18F]FEOBV PET, for rigorous experimental replication and validation of our primary hypothesis. We will correlate early COTC node (AC-I) cholinergic denervation with domain-specific and general measures of cognitive function. In a prospective analyses, we will determine if early COTC node (AC-I) cholinergic denervation predicts more rapid cognitive decline. In an integrated analysis with Project I, we will determine if COTC node (AC-I) cholinergic denervation is associated with Freezing of Gait (FoG). In exploratory analyses, we will assess if more accessible MRI or other measures correlate with COTC node (AC-I) cholinergic denervation, identifying potential, accessible biomarkers of COTC node (AC-I) cholinergic denervation. Project III will identify an important substrate of PD cognitive impairment and identify a PD subgroup with a more aggressive natural history – a “malignant hypocholinergic disease phenotype.” These results will identify potential targets for therapeutic interventions and biomarker development.

    Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration Dysfunction (Project Lead: Ahmed):

     Many patients with Parkinson’s disease (PD) suffer from spatial disorientation – inability to link external landmark cues to internal estimates of self-orientation. These deficits are not improved by dopamine replacement therapy (DRT). The same spatial disorientation features are found in patients with specific lesions, due to a stroke or hemorrhage, of the retrosplenial cortex (RSC), a brain region critical for encoding the combination of allocentric and egocentric navigational information. Attentional and emotional processing impairments in PD patients are accompanied by altered BOLD responses in the retrosplenial cortex. The retrosplenial cortex is densely interconnected with the secondary motor cortex, hippocampus, visual cortex, cingulate cortex and anterior thalamus (containing head orientation cells), and is therefore part of the Attentional-Motor Interface (AMI) and ideally positioned to help transform attentional and spatial information into planned actions. Furthermore, multiple basal forebrain structures send cholinergic projections to the RSC. There are pronounced increases in acetylcholine (ACh) release in the retrosplenial cortex during attentive spatial navigation. Cholinergic deficits, such as those seen in PD, are likely to severely impair the spatial orientation functions of the retrosplenial cortex. Little is known about 1) how cholinergic inputs influence the synapses, cells and circuits of the retrosplenial circuits, and 2) the impact of cholinergic dysfunction on retrosplenial-dependent spatial orientation and navigation. Our central hypothesis is that dysfunctional cholinergic systems projecting to the retrosplenial cortex will manifest in altered navigational encoding by retrosplenial circuits and spatially disoriented behaviors. We will decipher the mechanisms of cholinergic control of retrosplenial cells and synapses, with preliminary data suggesting both cell-type- and synapse-specific cholinergic controls. We will investigate how the loss of cholinergic inputs impairs retrosplenial encoding of space and how it impacts orientation-guided movement. These investigations will elucidate the contributions of the retrosplenial orientation coding circuit to the Attentional-Motor Interface, and lay the groundwork for understanding how altered perception of spatial orientation in Parkinson’s disease can directly impact motor control.

  • Udall Publications

    2023

    Automated production of [11C]butyrate for keto body PET imaging. Pakula RJ, Raffel DM, Koeppe RA, Winton WP, Stauff J, Bohnen NI, Albin RL, Scott PJH, Shao X. Nuclear medicine and biology. 2023 January;116-117:108315. PubMed PMID: 36680983; DOI: 10.1016/j.nucmedbio.2023.108315. PMCID: PMC10053181.

    Atrophy of the Cholinergic Basal Forebrain can Detect Presynaptic Cholinergic Loss in Parkinson's Disease. Ray NJ, Kanel P, Bohnen NI. Ann Neurol. 2023 Jan 4. doi: 10.1002/ana.26596. Epub ahead of print. PMID: 36597786. PMCID IN PROCESS

    2022

    Altered Cholinergic Innervation in De Novo Parkinson's Disease with and without Cognitive Impairment. van der Zee S, Kanel P, Gerritsen MJJ, Boertien JM, Slomp AC, Müller MLTM, Bohnen NI, Spikman JM, van Laar T. Mov Disord. 2022 Jan 17. doi: 10.1002/mds.28913. PMID: 35037719

    Automated Synthesis of 18F-BCPP-EF {2-tert-Butyl-4-chloro-5-{6-[2-(2[18F]fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one for Imaging of Mitochondrial Complex 1 in Parkinson’s Disease. Kaur T, Brooks AF, Liddell KM, Henderson BD, Bohnen NI, Albin RL, Scott PJH. Front Chem. 2022 Mar 30;10:878835. doi: 10.3389/fchem.2022.878835. PMID: 35433631; PMCID: PMC9005973.

    Cholinergic systems, attentional-motor integration, and cognitive control in Parkinson's disease. Albin RL, van der Zee S, van Laar T, Sarter M, Lustig C, Muller MLTM, Bohnen NI Prog Brain Res. 2022;269(1):345-371. doi: 10.1016/bs.pbr.2022.01.011. Epub 2022 Feb 4. PMID: 35248201. PMCID: PMC8957710

    Cerebral topography of vesicular cholinergic transporter changes in neurologically intact adults: A [18F]FEOBV PET study. Kanel P, van der Zee S, Sanchez-Catasus CA, Koeppe RA, Scott PJH, van Laar T, Albin RL, Bohnen NI. Aging Brain 2 (2022) 100039. https://doi.org/10.1016/j.nbas.2022.100039

    Cholinergic brain network deficits associated with vestibular sensory conflict deficits in Parkinson's disease: correlation with postural and gait deficits. Bohnen NI, Kanel P, Roytman S, Scott PJH, Koeppe RA, Albin RL, Kerber KA, Müller MLTM. Journal of neural transmission (Vienna, Austria : 1996). 2022 August;129(8):1001-1009. PubMed PMID: 35753016; PubMed Central PMCID: PMC9308723; DOI: 10.1007/s00702-022-02523-3.

    Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches. Bohnen NI, Yarnall AJ, Weil RS, Moro E, Moehle MS, Borghammer P, Bedard MA, Albin RL. Lancet Neurol. 2022 Apr;21(4):381-392. doi: 10.1016/S1474-4422(21)00377-X. Epub 2022 Feb 4. PMID: 35131038; PMCID: PMC8985079.

    Decreased vestibular efficacy contributes to abnormal balance in Parkinson's disease. Bohnen NI, Roytman S, Griggs A, David SM, Beaulieu ML, Müller MLTM. Journal of the neurological sciences. 2022 September 15;440:120357. PubMed PMID: 35932698; PubMed Central PMCID: PMC9444904; DOI: 10.1016/j.jns.2022.120357.

    Differential cholinergic systems' changes in progressive supranuclear palsy versus Parkinson's disease: an exploratory analysis. Kanel P, Spears CC, Roytman S, Koeppe RA, Frey KA, Scott PJH, Albin RL, Bohnen NI. Journal of neural transmission (Vienna, Austria : 1996). 2022 December;129(12):1469-1479. PubMed PMID: 36222971; PubMed Central PMCID: PMC10017092; DOI: 10.1007/s00702-022-02547-9.

    Discussion of Research Priorities for Gait Disorders in Parkinson's Disease. Bohnen NI, Costa RM, Dauer WT, Factor SA, Giladi N, Hallett M, Lewis SJG, Nieuwboer A, Nutt JG, Takakusaki K, Kang UJ, Przedborski S, Papa SM; MDS-Scientific Issues Committee. Mov Disord. 2022 Feb;37(2):253-263. PMID 34939221

    Dopamine neuron stimulation induces context-dependent abnormal involuntary movements in healthy rats. Hunter J, Bova A, Stevens A, Leventhal DK. 2022 Feb 22;25(3):103974. doi: 10.1016/j.isci.2022.103974. PMID: 35281727; PMCID: PMC8914546.

    Heterogeneous digital biomarker integration out-performs patient self-reports in predicting Parkinson's disease. Deng K, Li Y, Zhang H, Wang J, Albin RL, Guan Y. Commun Biol. 2022 Jan 17;5(1):58. doi: 10.1038/s42003-022-03002-x. PMID: 35039601; PMCID: PMC8763910.

    Identification of cholinergic centro-cingulate topography as main contributor to cognitive functioning in Parkinson's disease: Results from a data-driven approach. van der Zee S, Kanel P, Müller MLTM, van Laar T, Bohnen NI. Front Aging Neurosci. 2022 Oct 20;14:1006567. doi: 10.3389/fnagi.2022.1006567. PMID: 36337707; PMCID: PMC9631831.

    Imaging of sleep disorders in pre-Parkinsonian syndromes. Ota Y, Kanel P, Bohnen N. Curr Opin Neurol. 2022 Aug 1;35(4):443-452. doi: 10.1097/WCO.0000000000001084. Epub 2022 Jul 5. PMID: 35788559; PMCID: PMC9308698.

    No Dopamine Agonist Modulation of Brain [18F]FEOBV Binding in Parkinson's Disease. Albin RL, Kanel P, van Laar T, van der Zee S, Roytman S, Koeppe RA, Scott PJH, Bohnen NI. Mol Pharm. 2022 Apr 4;19(4):1176-1182. doi: 10.1021/acs.molpharmaceut.1c00961. Epub 2022 Mar 15. PMID: 35289620; PMCID: PMC8983523.

    Progression from Normal to MCI and from MCI to AD using Clinical Variables in the National Alzheimer’s Coordinating Center Uniform Data Set Version 3:  Application of Machine Learning Models and a Probability Calculator. Pang Y, Albin RL, Kukull W, Sano M, Shen C, Zhou J, and Dodge HH. Forthcoming in the Journal of Prevention of Alzheimer's Disease

    Progression of regional cortical cholinergic denervation in Parkinson's disease. Bohnen NI, Roytman S, Kanel P, Müller MLTM, Scott PJH, Frey KA, Albin RL, Koeppe RA. Brain Commun. 2022 Dec 2;4(6):fcac320. doi: 10.1093/braincomms/fcac320. PMID: 36569603; PMCID: PMC9772878.

    Running speed and REM sleep control two distinct modes of rapid interhemispheric communication. Ghosh M, Yang FC, Rice SP, Hetrick V, Gonzalez AL, Siu D, Brennan EKW, John TT, Ahrens AM, Ahmed OJ. Cell reports. 2022 July 5;40(1):111028. PubMed PMID: 35793619; PubMed Central PMCID: PMC9291430; DOI: 10.1016/j.celrep.2022.111028.

    Serotonin Transporter Imaging in Multiple System Atrophy and Parkinson's Disease. Chou KL, Dayalu P, Koeppe RA, Gilman S, Spears CC, Albin RL, Kotagal V. Mov Disord. 2022 Nov;37(11):2301-2307. doi: 10.1002/mds.29220. Epub 2022 Sep 14. PMID: 36102173; PMCID: PMC9669145.

    Striatal Acetylcholine-Dopamine Imbalance in Parkinson Disease: In Vivo Neuroimaging Study with Dual-Tracer PET and Dopaminergic PET-Informed Correlational Tractography. Sanchez-Catasus CA, Bohnen NI, D'Cruz N, Müller MLTM. J Nucl Med. 2022 Mar;63(3):438-445. doi: 10.2967/jnumed.121.261939. Epub 2021 Jul 16. PMID: 34272323. PMCID: PMC8978203.

    Vestibular Sensory Conflict During Postural Control, Freezing of Gait, and Falls in Parkinson's Disease. Bohnen NI, Kanel P, van Emde Boas M, Roytman S, Kerber KA. Mov Disord. 2022 Nov;37(11):2257-2262. doi: 10.1002/mds.29189. Epub 2022 Aug 15. PMID: 36373942; PMCID: PMC9673158.

     

    2021

    Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views. Kanel P, Bedard MA, Aghourian M, Rosa-Neto P, Soucy JP, Albin RL, Bohnen NI. Curr Neurol Neurosci Rep. 2021 Sep 20;21(10): doi: 10.1007/s11910-021-01140-z. PMID: 34545424.

    Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation. Yang Y, Gritton H, Sarter M, Aton SJ, Booth V, Zochowski M. PLoS Comput Biol 2021 Jul;17(7):e1009235. PMCID: PMC8357148.

    Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071. Kucinski A, Sarter M. Psychopharmacology (Berl) 2021 Jul;238(7):1953-1964. PMCID: PMC7969347

    α4β2*Nicotinic Cholinergic Receptor Target Engagement in Parkinson Disease Gait-Balance Disorders. Albin RL, Müller MLTM, Bohnen NI, Spino C, Sarter M, Koeppe RA, Szpara A, Kim K, Lustig C, Dauer WT. Ann Neurol. 2021 Jul;90(1):130-142. doi: 10.1002/ana.26102. Epub 2021 May 26. PMID: 33977560. PMCID: PMC9013471

    Repeat RNA Toxicity Drives Ribosomal RNA Processing Defects in SCA2. Skariah G, Albin RL. Mov Disord. 2021 Nov;36(11):2464-2467. doi: 10.1002/mds.28795. PMID: 34783387; PMCID: PMC8604384.

    Evolution of Gross Forelimb and Fine Digit Kinematics during Skilled Reaching Acquisition in Rats. Bova A, Ferris K, Leventhal DK. 2021 Oct 27;8(5):ENEURO.0153-21.2021. doi: 10.1523/ENEURO.0153-21.2021. PMID: 34625461; PMCID: PMC8555885.

    Regional cerebral cholinergic nerve terminal integrity and cardinal motor features in Parkinson's disease. Bohnen NI, Kanel P, Koeppe RA, Sanchez-Catasus CA, Frey KA, Scott P, Constantine GM, Albin RL, Müller MLTM. Brain Commun. 2021 May 22;3(2):fcab109. doi: 10.1093/braincomms/fcab109. PMID: 34704022; PMCID: PMC8196256.

    Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease. van der Zee S, Müller MLTM, Kanel P, van Laar T, Bohnen NI. Mov Disord. 2021 Mar;36(3):642-650. doi: 10.1002/mds.28360. Epub 2020 Nov 2. PMID: 33137238; PMCID: PMC7988481.

    Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements. Sarter M, Avila C, Kucinski A, Donovan E. Mov Disord. 2021 Mar;36(3):535-546. doi: 10.1002/mds.28532. Epub 2021 Feb 22. PMID: 33615556; PMCID: PMC8938956.

    Precisely timed dopamine signals establish distinct kinematic representations of skilled movements. Bova A, Gaidica M, Hurst A, Iwai Y, Hunter J, Leventhal DK. Elife. 2020 Nov 27;9:e61591. doi: 10.7554/eLife.61591. PMID: 33245045; PMCID: PMC7861618.

    New Developments in Cholinergic Imaging in Alzheimer and Lewy Body Disorders. Craig CE, Ray NJ, Müller MLTM, Bohnen NI. Curr Behav Neurosci Rep. 2020 Dec;7(4):278-286. doi: 10.1007/s40473-020-00221-6. Epub 2020 Oct 9. PMID: 33777646; PMCID: PMC7992054.

    Phasic cholinergic signaling promotes emergence of local gamma rhythms in excitatory-inhibitory networks. Lu Y, Sarter M, Zochowski M, Booth V. Eur J Neurosci 2020;52(6):3545-3560. PMCID: PMC8054224

    Dopaminergic Nigrostriatal Connectivity in Early Parkinson Disease: In Vivo Neuroimaging Study of 11C-DTBZ PET Combined with Correlational Tractography. Sanchez-Catasus CA, Bohnen NI, Yeh FC, D'Cruz N, Kanel P, Müller MLTM. J Nucl Med. 2021 Apr;62(4):545-552. doi: 10.2967/jnumed.120.248500. Epub 2020 Aug 28. PMID: 32859707. PMCID: PMC8973250.

    Molecular Imaging of the Cholinergic System in Alzheimer and Lewy Body Dementias: Expanding Views. Kanel P, Bedard MA, Aghourian M, Rosa-Neto P, Soucy JP, Albin RL, Bohnen NI. Curr Neurol Neurosci Rep. 2021 Sep 20;21(10):52. doi: 10.1007/s11910-021-01140-z. PMID: 34545424; PMCID: PMC9020458.

    2020
    1. Aging, Vestibular Function, and Balance: Proceedings of a National Institute on Aging/National Institute on Deafness and Other Communication Disorders Workshop. Agrawal Y, Merfeld DM, Horak FB, Redfern MS, Manor B, Westlake KP, Holstein GR, Smith PF, Bhatt T, Bohnen NI, Lipsitz LA.. J Gerontol A Biol Sci Med Sci. 2020 Nov 13;75(12):2471-2480. doi: 10.1093/gerona/glaa097. PMID: 32617555; PMCID: PMC7662183.
    1. Cholinergic Denervation Patterns Across Cognitive Domains in Parkinson's Disease. van der Zee S, Müller MLTM, Kanel P, van Laar T, Bohnen NI. Mov Disord. 2020 Nov 2. doi: 10.1002/mds.28360. Epub ahead of print. PMID: 33137238.
    1. Body-first versus brain-first biological subtyping of Parkinson's disease. Bohnen NI, Postuma RB. Brain. 2020 Oct 1;143(10):2871-2873. doi: 10.1093/brain/awaa293. PMID: 33103732. PMC Journal in process
    1. A failed future. Albin RL, Kordower JH. Mov Disord. 2020 Aug;35(8):1299-1301. doi: 10.1002/mds.28130. PMID: 32780511.
    1. Resting state connectivity within the basal ganglia and gait speed in older adults with cerebral small vessel disease and locomotor risk factors. Karim HT, Rosso A, Aizenstein HJ, Bohnen NI, Studenski S, Rosano C. Neuroimage Clin. 2020 Aug 28;28:102401. doi: 10.1016/j.nicl.2020.102401. Epub ahead of print. PMID: 32932053; PMCID: PMC7495101.
    1. Vulnerabilities of Aging and Biological Effects of Physical Activity Provide New Clues for Interventions in Parkinson's Disease. Bohnen NI. J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):687-689. doi: 10.1093/gerona/glaa026. PMID: 32150615. PMC Journal in process
    1. Compressive Big Data Analytics: An ensemble meta-algorithm for high-dimensional multisource datasets. Marino S, Zhao Y, Zhou N, Zhou Y, Toga AW, Zhao L, Jian Y, Yang Y, Chen Y, Wu Q, Wild J, Cummings B, Dinov ID. PLoS One. 2020 Aug 28;15(8):e0228520. doi: 10.1371/journal.pone.0228520. PMID: 32857775; PMCID: PMC7455041.
    1. Development and validation of the automated imaging differentiation in Parkinsonism (AID-P): A multi-site machine learning study. Archer DB, Bricker JT, Chu WT, Burciu RG, Mccracken JL, Lai S, Coombes SA, Fang R, Barmpoutis A, Corcos DM, Kurani AS, Mitchell T, Black ML, Herschel E, Simuni T, Parrish TB, Comella C, Xie T, Seppi K, Bohnen NI, Müller MLTM, Albin RL, Krismer F, Du G, Lewis MM, Huang X, Li H, Pasternak O, McFarland NR, Okun MS, Vaillancourt DE. Lancet Digit Health. 2019 Sep;1(5):e222-e231. doi: 10.1016/s2589-7500(19)30105-0. Epub 2019 Aug 27. PMID: 32259098; PMCID: PMC7111208.
    1. Current and projected future economic burden of Parkinson's disease in the U.S. Yang W, Hamilton JL, Kopil C, Beck JC, Tanner CM, Albin RL, Ray Dorsey E, Dahodwala N, Cintina I, Hogan P, Thompson T. NPJ Parkinsons Dis. 2020 Jul 9;6:15. doi: 10.1038/s41531-020-0117-1. PMID: 32665974; PMCID: PMC7347582.
    1. Seizure occurrence and related mortality in dementia with Lewy bodies. Marawar R, Wakim N, Albin RL, Dodge H. Epilepsy Behav. 2020 Jul 18;111:107311. doi: 10.1016/j.yebeh.2020.107311. Epub ahead of print. PMID: 32693380. PMCID: PMC7541707
    1. Deep learning identifies digital biomarkers for self-reported Parkinson's disease. Zhang H, Deng K, Li H, Albin RL, Guan Y. Patterns (N Y). 2020 Jun 12;1(3):100042. doi: 10.1016/j.patter.2020.100042. Epub 2020 May 28. PMID: 32699844; PMCID: PMC7375444.
    1. Topography of cholinergic changes in dementia with Lewy bodies and key neural network hubs. Kanel P, Müller MLTM, van der Zee S, Sanchez-Catasus CA, Koeppe RA, Frey KA, Bohnen NI. J Neuropsychiatry Clin Neurosci. 2020 Jun 5:appineuropsych19070165. doi: 10.1176/appi.neuropsych.19070165. Epub ahead of print. PMID: 32498602.
    2. Phasic cholinergic signaling promotes emergence of local gamma rhythms in excitatory-inhibitory networks. Lu Y, Sarter M, Zochowski M, Booth V. [published online ahead of print, 2020 Apr 15]. Eur J Neurosci. 2020;10.1111/ejn.14744. doi:10.1111/ejn.14744
    1. Forebrain cholinergic signaling: Wired and phasic, not tonic, and causing behavior. Sarter M, Lustig C. J Neurosci. 2020 Jan 22;40(4):712-719. doi: 10.1523/JNEUROSCI.1305-19.2019. PMID:  31969489 PMCID: PMC6975286
    1. Diffusion magnetic resonance imaging-derived free water detects neurodegenerative pattern induced by interferon-γ. Febo M, Perez PD, Ceballos-Diaz C, et al. Brain Struct Funct. 2020;225(1):427-439. doi:10.1007/s00429-019-02017-1. PMID: 31894407 PMCID: PMC7003714
    1. Correction to: Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson's disease. Cherian AK, Kucinski A, Wu R, de Jong IEM, Sarter M. Psychopharmacology (Berl). 2020;237(1):289. doi:10.1007/s00213-019-05375-0. PMID: 31650233
    1. HDQLIFE and neuro-QoL physical function measures: Responsiveness in persons with huntington's disease. Carlozzi NE, Boileau NR, Chou KL, Ready RE, Cella D, McCormack MK, Miner JA, Dayalu P. Mov Disord. 2020;35(2):326-336. doi:10.1002/mds.27908. PMID: 31724237 PMCID: PMC7041888.
    2. Complex movement control in a rat model of Parkinsonian falls: bidirectional control by striatal cholinergic interneurons. Sarter M, Avila C, Kucinski A. J Neurosci. 2020 Jun 18:JN-RM-0220-20. doi: 10.1523/JNEUROSCI.0220-20.2020. Epub ahead of print. PMID: 32554512. PMCID: PMC7392507.
    1. Apathy rating scores and β-amyloidopathy in patients with Parkinson disease at risk for cognitive decline. Zhou Z, Müller MLTM, Kanel P, Chua J, Kotagal V, Kaufer DI, Albin RL, Frey KA, Bohnen NI. Neurology. 2020 Jan 28;94(4):e376-e383. doi: 10.1212/WNL.0000000000008683. Epub 2019 Nov 15. PMID: 3173256 PMCID: PMC7079689
    2. Increased striatal dopamine in carriers of GBA mutations: compensation or epiphenomenon? Bohnen NI, Albin RL. Lancet Neurol. 2020 Jan;19(1):27-29. doi: 10.1016/S1474-4422(19)30355-2. Epub 2019 Oct 31. No abstract available. PMID: 31678033. PMCID: PMC6924570
    1. Freezing of gait: understanding the complexity of an enigmatic phenomenon. Weiss D, Schoellmann A, Fox MD, Bohnen NI, Factor SA, Nieuwboer A, Hallett M, Lewis SJG. Brain. 2020 Jan 1;143(1):14-30. doi: 10.1093/brain/awz314. PMID: 31647540 PMCID: PMC6938035
    2. Precisely timed dopamine signals establish distinct kinematic representations of skilled movements. Bova A, Gaidica M, Hurst A, Iwai Y, Hunter J, Leventhal DK.  Elife. 2020 Nov 27;9:e61591. doi: 10.7554/eLife.61591. PMID: 33245045; PMCID: PMC7861618.
    3. New Developments in Cholinergic Imaging in Alzheimer and Lewy Body Disorders. Craig CE, Ray NJ, Müller MLTM, Bohnen NI.  Curr Behav Neurosci Rep. 2020 Dec;7(4):278-286. doi: 10.1007/s40473-020-00221-6. Epub 2020 Oct 9. PMID: 33777646; PMCID: PMC7992054.
    2019
    1. Tourette Syndrome as a Disorder of the Social Decision Making Network. Albin RL. Front Psychiatry. 2019 Oct 8;10:742. doi: 10.3389/fpsyt.2019.00742. PMID: 31649568; PMCID: PMC6792345.
    1. Treatment options for postural instability and gait difficulties in Parkinson's disease. Müller MLTM, Marusic U, van Emde Boas M, Weiss D, Bohnen NI. Expert Rev Neurother. 2019 Dec;19(12):1229-1251. doi: 10.1080/14737175.2019.1656067. Epub 2019 Aug 30. PMID: 31418599
    1. HDDA: DataSifter: Statistical obfuscation of electronic health records and other sensitive datasets. Marino S, Zhou N, Zhao Yi, Wang L, Wu Q, Dinov ID. Journal of Statistical Computation and Simulation, Vol 89:2, 249-271. 2019.doi: 10.1080/00949655.2018.1545228. PMID: 30962669. PMCID: PMC6450541
    1. Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease.Koshy Cherian A, Kucinski A, Wu R, de Jong IEM, Sarter M. Psychopharmacology 04 January 2019, 1-15. PMID: 30607479
    1. The contribution of cerebrovascular risk factors, metabolic and inflammatory changes to cognitive decline in Parkinson’s disease - preliminary observations. Veselý B, Koriťáková E, Bohnen NI, Viszlayová D, Királová S, Valkovič P, Kurča E & Rektor I (2019)  J Neural Transm (Vienna).2019 Oct;126(10):1303-1312. doi: 10.1007/s00702-019-02043-7. Epub 2019 Jul 22. PMID: 31332506. PMCID: PMC6959128
    1. The open diffusion data derivatives, brain data upcycling via integrated publishing of derivatives and reproducible open cloud services.Avesani P, McPherson B, Hayashi S, Caiafa CF, Henschel R, Garyfallidis E, Kitchell L, Bullock D, Patterson A, Olivetti E, Sporns O, Saykin AJ, Wang L, Dinov I, Hancock D, Caron B, Qian Y, Pestilli F. Sci Data. 2019 May 23;6(1):69. doi:10.1038/s41597-019-0073-y. PubMed PMID: 31123325; PubMed Central PMCID: PMC6533280.
    1. Predictive big data analytics using the UK Biobank Data. Zhou Y, Zhao L, Zhou N, Zhao Y, Marino S, Wang T, Sun H, Toga AW, Dinov ID. Sci Rep. 2019 Apr 12;9(1):6012. doi: 10.1038/s41598-019-41634-y. PubMed PMID: 30979917; PubMed Central PMCID: PMC6461626.
    1. Fatigue in Parkinson's disease associates with lower ambulatory diastolic blood pressure. Kotagal V, Szpara A, Albin RL, Bohnen NI. J Parkinsons Dis.2019;9(3):575-581. doi: 10.3233/JPD-191579. PubMed PMID: 31156183; PubMed Central PMCID: PMC6682445.
    1. Polyglutamine repeats in neurodegenerative diseases. Lieberman AP, Shakkottai VG, Albin RL. Annu Rev Pathol. 2019 Jan 24;14:1-27. doi:10.1146/annurev-pathmechdis-012418-012857. Epub 2018 Aug 8. PubMed PMID:30089230; PubMed Central PMCID: PMC6387631.
    1. Complementary motivational roles of nigroaccumbens and nigrostriataldopaminergic pathways.Mov Disord. Albin RL. 2019 Jan;34(1):45. doi: 10.1002/mds.27504.PubMed PMID: 30653732.   PubMed Central PMCID:  PMCID:PMC6812511
    1. The cortical cholinergic system contributes to the top-down control of distraction: Evidence from patients with Parkinson's disease.Kim K, Müller, MLT, Bohnen NI, Sarter M, Lustig C. (2019). NeuroImage, 190, 107-117. PubMed Central PMCID:  PMCID: PMC6008164
    1. Sleep disturbance as potential risk and progression factor for Parkinson's disease.Bohnen NI, Hu MTM. J Parkinsons Dis. 2019;9(3):603-614. doi: 10.3233/JPD-191627. PMID: 31227656. PubMed Central PMCID: PMC6700634
    1. Effects of plasma glucose levels on regional cerebral 18F-fluorodeoxyglucose uptake: Implications for dementia evaluation with brain PET imaging.Viglianti BL, Wale DJ, Ma T, Johnson TD, Bohnen NI, Wong KK, Ky C, Frey KA, Townsend DM, Rubello D, Gross MD. Biomed Pharmacother. 2019 Apr;112:108628. doi: 10.1016/j.biopha.2019.108628. Epub 2019 Feb 20. PMID: 30784923 PubMed Central PMCID: PMC6714976
    1. Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System.van Eimeren T, Antonini A, Berg D, Bohnen N, Ceravolo R, Drzezga A, Höglinger GU, Higuchi M, Lehericy S, Lewis S, Monchi O, Nestor P, Ondrus M, Pavese N, Peralta MC, Piccini P, Pineda-Pardo JÁ, Rektorová I, Rodríguez-Oroz M, Rominger A, Seppi K, Stoessl AJ, Tessitore A, Thobois S, Kaasinen V, Wenning G, Siebner HR, Strafella AP, Rowe JB. Alzheimers Dement (Amst). 2019 Apr 2;11:301-309. doi: 10.1016/j.dadm.2019.01.011. eCollection 2019 Dec. PubMed PMID: 30984816; PubMed Central PMCID: PMC6446052.
    1. Cholinergic system changes of falls and freezing of gait in Parkinson disease. Bohnen NI, Kanel P, Zhou Z, Koeppe RA, Frey KA, Dauer WT, Albin RL, Müller MLTM Annals of Neurology. 2019 Feb 5. doi: 10.1002/ana.25430. [Epub ahead of print]. PMID: 30720884 PMCID: PMC6450746
    1. Multimodal dopaminergic and free-water imaging in Parkinson's disease.Yang J, Archer DB, Burciu RG, Müller MLTM, Roy A, Ofori E, Bohnen NI, Albin RL, Vaillancourt DE. Parkinsonism Relat Disord. 2019 May;62:10-15. doi: 10.1016/j.parkreldis.2019.01.007. Epub 2019 Jan 6. PubMed PMID: 30639168; PubMed  Central PMCID: PMC6589363.
    1. Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [(18)F]-FEOBV.Nejad-Davarani S, Koeppe RA, Albin RL, Frey KA, Müller MLTM, Bohnen NI. Mol Psychiatry. 2019 Mar;24(3):322-327. doi: 10.1038/s41380-018-0130-5. Epub 2018 Aug 6. PubMed PMID: 30082840; PubMed Central PMCID: PMC6363916.
    1. Cholinergic double duty: cue detection and attentional control.Sarter M, Lustig C. Curr Opin Psychol. 2019, 29:102-107. PubMed PMID: 30711909; PMCID: PMC6609491
    1. Basal forebrain chemogenetic inhibition disrupts the superior complex movement control of goal-tracking rats. Kucinski A, Kim Y, Sarter M. Behavioral Neuroscience 133(1), 121-134. 2019. doi: 10.1037/bne0000290. DOI: 1037/bne0000290  PMID:30688488   PMCID:  PMC6850517
    2. The open diffusion data derivatives, brain data upcycling via integrated publishing of derivatives and reproducible open cloud services. Avesani P, McPherson B, Hayashi S, Caiafa CF, Henschel R, Garyfallidis E, Kitchell L, Bullock D, Patterson A, Olivetti E, Sporns O, Saykin AJ, Wang L, Dinov I, Hancock D, Caron B, Qian Y, Pestilli F. Sci Data. 2019 May 23;6(1):69. doi: 10.1038/s41597-019-0073-y. PMID: 31123325; PMCID: PMC6533280.
    3. Model-based and model free techniques for Amyotrophic Lateral Sclerosis diagnostic prediction and patient clustering. Tang M, Gao C, Goutman SA, Kalinin A, Mukherjee B, Guan Y, Dinov ID. Neuroinformatics. 2019 Jul;17(3):407-421. doi: 10.1007/s12021-018-9406-9. PMID: 30460455; PMCID: PMC6527505.
    4. Machine learning techniques for personalized breast cancer risk prediction: comparison with the BCRAT and BOADICEA models. Ming C, Viassolo V, Probst-Hensch N, Chappuis PO, Dinov ID, Katapodi MC Breast Cancer Res. 2019;21(1):75. Published 2019 Jun 20. doi:10.1186/s13058-019-1158-4. PMID: 31221197. PMCID: PMC6585114850517
    2018
    1. Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson’s disease. Kim K, Bohnen NI, Müller MLTM, Lustig C. 2019 Apr 15;190:94-106. doi: 10.1016/j.neuroimage.2018.01.021. Epub 2018 Jan 11. PMID: 29337277; PMCID: PMC6041186.
    2. Deep learning in pharmacogenomics: from gene regulation to patient stratification. Kalinin AA, Higgins GA, Reamaroon N, Soroushmehr S, Allyn-Feuer A, Dinov ID, Najarian K, Athey BD. Pharmacogenomics. 2018 May;19(7):629-650. doi: 10.2217/pgs-2018-0008. Epub 2018 Apr 26. Review. PMID: 29697304 PMCID: PMC6022084
    3. Non-dopaminergic therapies.Nutt JG, Bohnen NI. J Parkinsons Dis. 2018;8(s1):S73-S78. doi: 10.3233/JPD-181472. Review. PMID:30584157  PubMed Central PMCID: PMC6311374
    1. The 10-year Landscape of United States-Registered Parkinson Disease Clinical Trials:Wyant KJ, Yasuda E, Kotagal V. 2007-2016. Mov Disord Clin Pract. 2018 Oct 4;5(5):512-518. doi: 10.1002/mdc3.12665. eCollection 2018 Sep-Oct PMID:  30515440  PMCID: PMC6207117
    2. Serotonin, beta-amyloid, and cognition in Parkinson disease. Kotagal V, Spino C, Bohnen NI, Koeppe R, Albin RL. Ann Neurol. 2018 May;83(5):994-1002. PubMed PMID: 29665066; PubMed Central PMCID: PMC6021203; DOI: 10.1002/ana.25236.
    3. Imaging markers of progression in Parkinson's disease.Strafella AP, Bohnen NI, Pavese N, Vaillancourt DE, van Eimeren T, Politis M, Tessitore A, Ghadery C, Lewis S; IPMDS‐Neuroimaging Study Group. Mov Disord Clin Pract. 2018 Oct 9;5(6):586-596. doi: 10.1002/mdc3.12673. eCollection 2018 Nov-Dec. Review. PMID: 30637278 PubMed Central PMCID: PMC6277366
    4. Regional vesicular acetylcholine transporter distribution in human brain: A [18F]Fluoroethoxy benzovesamicol Positron Emission Tomography Study. Albin RL, Müller MLT, Bohnen NI, Dauer WT, Sarter M, Frey KA, Koeppe RA. J Comp Neurol.2018 Dec 1;526(17):2884-2897. doi: 10.1002/cne.24541. Epub 2018 Oct 19.
    5. Finding useful biomarkers for Parkinson's disease.Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A,Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M,German D, Gwinn K, Huang X, Kopil C, Kremer T, Lasch S, Marek K, Marto JA,Merchant K, Mollenhauer B, Naito A, Potashkin J, Reimer A, Rosenthal LS,Saunders-Pullman R, Scherzer CR, Sherer T, Singleton A, Sutherland M, Thiele I,van der Brug M, Van Keuren-Jensen K, Vaillancourt D, Walt D, West A, Zhang J. Sci Transl Med. 2018 Aug15;10(454). pii: eaam6003. doi: 10.1126/scitranslmed.aam6003. Review. PubMedPMID: 30111645; PubMed Central PMCID: PMC6097233.
    6. 3D shape modeling for cell nuclear morphological analysis and classification. Kalinin AA, Allyn-Feuer A, Ade A, Fon GF, Meixner W, Dilworth D, Husain SS, de Wet JR, Higgins GA, Zheng G, Creekmore A, Wiley JW, Verdone JE, Veltri RW, Pienta KJ, Coffey DS, Athey BD, Dinov ID. Sci Rep. 2018; 8: 13658. Published online 2018 Sep 12. doi: 10.1038/s41598-018-31924-2 Correction in: Sci Rep. 2018; 8: 16142.  PMCID:  PMC6135819
    7. Controlled feature selection and compressive big data analytics: Applications to biomedical and health studies. Marino, S, Xu, J, Zhao, Y, Zhou, N, Zhou, Yi, Dinov, ID. PLoS One. 2018; 13(8): e0202674. Published online 2018 Aug 30. doi: 10.1371/journal.pone.0202674 PMCID: PMC6116997
    8. ‘Hot’ vs. ‘cold’ behavioural-cognitive styles: motivational-dopaminergic vs. cognitive-cholinergic processing of a Pavlovian cocaine cue in sign- and goal-tracking rats. Pitchers KK, Kane LF, Kim Y, Robinson TE, Sarter M. Eur J Neurosci. 2017 Dec; 46(11): 2768–2781. Published online 2017 Nov 6. doi: 10.1111/ejn.13741. PMCID:  PMC6088792
    9. Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board. Albin RL, Surmeier DJ, Tubert C, Sarter M, Müller MLTM, Bohnen NI, Dauer WT. Mov Disord. 2018 Nov 6. doi: 10.1002/mds.27540. [Epub ahead of print] No abstract available. PMID:  30398673
    10. Regional subcortical shape analysis in premanifest Huntington's disease. Tang X, Ross CA, Johnson H, Paulsen JS, Younes L, Albin RL, Ratnanather JT, Miller MI. Hum Brain Mapp. 2018 Oct 30. doi: 10.1002/hbm.24456. [Epub ahead of print.] PMID:  30376191
    11. Molecular imaging of the cholinergic system in Parkinson's disease. Bohnen NI, Kanel P, Müller MLTM. Int Rev Neurobiol. 2018;141:211-250. doi: 10.1016/bs.irn.2018.07.027. Epub 2018 Sep 20. PMID: 30314597 PMCID: PMC6218162
    12. Randomization-based statistical inference: A resampling and simulation infrastructure. Dinov ID, Palanimalai S, Khare A, Christou N. Teach Stat. 2018 Summer;40(2):64-73. doi: 10.1111/test.12156. Epub 2018 Apr 11. PMID:  30270947. PMCID: PMC6155997
    13. Hypothesis: Caco-2 cell rotational 3D mechanogenomic turing patterns have clinical implications to colon crypts. Zheng G, Kalinin AA, Dinov ID, Meixner W, Zhu S, Wiley JW. J Cell Mol Med. 2018 Dec;22(12):6380-6385. doi: 10.1111/jcmm.13853. Epub 2018 Sep 25. PMID:  30255651 PMCID: PMC6237597
    14. The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target. Petyuk VA, Chang R, Ramirez-Restrepo M, Beckmann ND, Henrion MYR, Piehowski PD, Zhu K, Wang S, Clarke J, Huentelman MJ, Xie F, Andreev V, Engel A, Guettoche T, Navarro L, De Jager P, Schneider JA, Morris CM, McKeith IG, Perry RH, Lovestone S, Woltjer RL, Beach TG, Sue LI, Serrano GE, Lieberman AP, Albin RL, Ferrer I, Mash DC, Hulette CM, Ervin JF, Reiman EM, Hardy JA, Bennett DA, Schadt E, Smith RD, Myers AJ. Brain. 2018 Aug 20. doi: 10.1093/brain/awy215. PMID: 30137212 PMCID: PMC6136080
    15. Big data analytical approaches to the NACC dataset: Aiding preclinical trial enrichment. Lin M, Gong P, Yang T, Ye J, Albin RL, Dodge HH. Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):18-27. doi: 10.1097/WAD.0000000000000228. PMID: 29227306 PMCID: PMC5854492
    16. Model-based and model-free machine learning techniques for diagnostic prediction and classification of clinical outcomes in Parkinson's disease. Gao C, Sun H, Wang T, Tang M, Bohnen NI, Müller MLTM, Herman T, Giladi N, Kalinin A, Spino C, Dauer W, Hausdorff JM, Dinov ID. Sci Rep. 2018 May 8;8(1):7129. doi: 10.1038/s41598-018-24783-4. PMID: 29740058
    17. An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group. Rektor I, Bohnen NI, Korczyn AD, Gryb V, Kumar H, Kramberger MG, de Leeuw FE, Pirtošek Z, Rektorová I, Schlesinger I, Slawek J, Valkovič P, Veselý B. Parkinsonism & related disorders. 2018 April;49:9-16. PubMed PMID: 29310988; PubMed Central PMCID: PMC5857227.
    18. Cardiovascular risk factor burden in veterans and non-veterans with Parkinson Disease. Kotagal V, Albin RL, Müller MLTM, Bohnen NI. J Parkinsons Dis. 2018;8(1):153-160. doi: 10.3233/JPD-171271. PMID: 29480230 PubMed Central PMCID: PMC5872149.
    19. The hot 'n' cold of cue-induced drug relapse. Pitchers KK, Sarter M, Robinson TE. Learn Mem. 2018 Aug 16;25(9):474-480. doi: 10.1101/lm.046995.117. Print 2018 Sep. PMID: 30115769 PMCID: PMC6097766
    20. Addiction vulnerability trait impacts complex movement control: Evidence from sign-trackers. Kucinski A, Lustig C, Sarter M. Behav Brain Res. 2018 Sep 17;350:139-148. doi: 10.1016/j.bbr.2018.04.045. Epub 2018 Apr 26. PMID: 29705686
    21. Vascular and dopaminergic contributors to mild parkinsonian signs in older adults.Rosso AL, Bohnen NI, Launer LJ, Aizenstein HJ, Yaffe K, Rosano C. Neurology. 2018 January 16;90(3):e223-e229. PubMed PMID: 29247072; PubMed Central PMCID: PMC5772161.
    22. Tourette syndrome: a disorder of the social decision-making network.Albin RL. Brain: a journal of neurology. 2018 February 1;141(2):332-347. PubMed PMID: 29053770; PubMed Central PMCID: PMC5837580.
    23. The neuroscience of cognitive-motivational styles: Sign- and goal-trackers as animal models. Behavioral neuroscience.Sarter M, Phillips KB. 2018 February;132(1):1-12. PubMed PMID: 29355335; PubMed Central PMCID: PMC5881169.
    24. Reader response: Odor identification as a biomarker of preclinical AD in older adults at risk.Bohnen NI, Muller M. 2018 February 13;90(7):343. PubMed PMID: 29440547.
    1. A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.Antoniou N, Vlachakis D, Memou A, Leandrou E, Valkimadi PE, Melachroinou K, Re DB, Przedborski S, Dauer WT, Stefanis L, Rideout HJ. Scientific reports. 2018 February 22;8(1):3455. PubMed PMID: 29472595; PubMed Central PMCID: PMC5823876.
    2. Recent advances in cholinergic imaging and cognitive decline-Revisiting the cholinergic hypothesis of dementia. Current geriatrics reports.Bohnen NI, Grothe MJ, Ray NJ, Müller MLTM, Teipel SJ. 2018 March;7(1):1-11. PubMed PMID: 29503795; PubMed Central PMCID: PMC5831510.
    3. Subtype definition of vascular parkinsonism.Rektor I, Bohnen NI, Korczyn AD. Parkinsonism & related disorders. 2018 March 9. PubMed PMID: 29544882. PMCID: PMC6019183
    4. Hypercholinergic activity in LRRK2 Parkinson's disease. Bohnen NI, Albin RL. The Lancet. Neurology. 2018 April;17(4):290-291. PubMed PMID: 29456160; PubMed Central PMCID: PMC5858987
    5. Peripheral neuropathy is associated with more frequent falls in Parkinson's disease. Parkinsonism & related disorders. Beaulieu ML, Müller MLTM, Bohnen NI. 2018 April 3. PubMed PMID: 29625874.
    6. Cholinergic forebrain density loss in Parkinson disease: More than just cognitive changes.Bohnen NI, Teipel SJ. Neurology. 2018 April 4. PubMed PMID: 29618621.
    7. A computerized microelectrode recording to magnetic resonance imaging mapping system for subthalamic nucleus Deep Brain Stimulation Surgery. Dodani SS, Lu CW, Aldridge JW, Chou KL, Patil PG. Oper Neurosurg (Hagerstown). 2018 Jun 1;14(6):661-667. doi: 10.1093/ons/opx169. PMID: 28961898; PMCID: PMC6888019.
    2017
    1. Complete hazard ranking to analyze right-censored data: An ALS survival study.Huang Z, Zhang H, Boss J, Goutman SA, Mukherjee B, Dinov ID, Guan Y. PLoS computational biology. 2017 December;13(12):e1005887. PubMed PMID: 29253881; PubMed Central PMCID: PMC5749893.
    2. Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease.Miller NS, Chou KL, Bohnen NI, Müller MLTM, Seidler RD. Parkinsonism Relat Disord. 2017 Dec 12. pii: S1353-8020(17)30836-2. doi: 10.1016/j.parkreldis.2017.12.010. [Epub ahead of print] PMID:29249680 PMCID: PMC5826846
    3. Color discrimination errors associate with axial motor impairments in Parkinson's disease. Bohnen NI, Haugen J, Ridder A, Kotagal V, Albin RL, Frey KA, Müller MLTM. Mov Disord Clin Pract. 2017 Nov-Dec;4(6):864-869. doi: 10.1002/mdc3.12527. Epub 2017 Sep 8. PMID:29226177 PMCID: PMC5716634
    4. Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity.Koshy Cherian A, Parikh V, Wu Q, Mao-Draayer Y, Wang Q, Blakely RD, Sarter M. Neurochemistry international. 2017 September;108:410-416. PubMed PMID: 28577989; PubMed Central PMCID: PMC5524217.
    5. Polyglutamine inclusion body toxicity. Albin RL. Mov Disord. 2017 Dec;32(12):1686. doi: 10.1002/mds.27226. Epub 2017 Nov 9. PMID: 29119663 PMCID: PMC5744902
    6. Mentally stimulating activities associate with better cognitive performance in Parkinson disease.Bohnen JLB, Müller MLTM, Haugen J, Bohnen NI. J Neural Transm (Vienna). 2017 Oct;124(10):1205-1212. doi: 10.1007/s00702-017-1761-4. Epub 2017 Jul 19. PMID:28726034. PMCID:PMC5693756
    7. Many genes involved in Tourette syndrome pathogenesis. Albin RL. Movement disorders: official journal of the Movement Disorder Society. 2017 July;32(7):993. PubMed PMID: 28594134; PubMed Central PMCID: PMC5528167.
    8. Normal striatal vesicular acetylcholine transporter expression in Tourette Syndrome.Albin RL, Minderovic C, Koeppe RA.   2017 July;4(4). PubMed PMID: 28791334; PubMed Central PMCID: PMC5547197.
    9. Molecular imaging and updated diagnostic criteria in Lewy body dementias.Bohnen NI, Müller MLTM, Frey KA. Curr Neurol Neurosci Rep. 2017 Aug 14;17(10):73. doi: 10.1007/s11910-017-0789-z. Review. PMID:  28808912 PMCID: PMC5873980
    10. Mitigating the burden of neurological disease.Albin RL. Annals of neurology. 2017 August;82(2):315. PubMed PMID: 28752897; PubMed Central PMCID: PMC5870892.
    11. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K. Neurology. 2017 Jul 4;89(1):88-100. doi: 10.1212/WNL.0000000000004058. Epub 2017 Jun 7. Review. PMID:  28592453  PMCID: PMC5496518
    12. The missing, the short, and the long: Levodopa responses and dopamine actions.Albin RL, Leventhal DK. Ann Neurol. 2017 Jul;82(1):4-19. doi: 10.1002/ana.24961. Epub 2017 Jun 5. No abstract available. PMID:28543679. PMCID: PMC5526730
    13. Association between autonomic dysfunction and fatigue in Parkinson disease.Chou KL, Gilman S, Bohnen NI. J Neurol Sci. 2017 Jun 15;377:190-192. doi: 10.1016/j.jns.2017.04.023. Epub 2017 Apr 17. PMID: 28477694  PMCID:PMC5536106
    14. Have we been overestimating fall rates in Parkinson's disease? Beaulieu ML, Müller MLTM, Bohnen NI. Mov Disord. 2017 May;32(5):803. doi: 10.1002/mds.26994. Epub 2017 Apr 21. No abstract available.  PMID:  28429881
    15. SOCRAT platform design: A web architecture for interactive visual analytics applications.Proceedings of the 2nd Workshop on Human-In-the-Loop Data Analytics. Kalinin AA, Palanimalai S, Dinov ID. (2nd :2017 : Chicago, Ill.). 2017 April; 2017. PubMed PMID: 29630069; PubMed Central PMCID: PMC5884130.
    16. Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program.Gwinn K, David KK, Swanson-Fischer C, Albin R, Hillaire-Clarke CS, Sieber BA, Lungu C, Bowman FD, Alcalay RN, Babcock D, Dawson TM, Dewey RB Jr, Foroud T, German D, Huang X, Petyuk V, Potashkin JA, Saunders-Pullman R, Sutherland M, Walt DR, West AB, Zhang J, Chen-Plotkin A, Scherzer CR, Vaillancourt DE, Rosenthal LS. Biomark Med. 2017 May;11(6):451-473. doi: 10.2217/bmm-2016-0370. Epub 2017 Jun 23. PMID: 28644039. PMCID:PMC5619098
    17. Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort.Chou KL, Elm JJ, Wielinski CL, Simon DK, Aminoff MJ, Christine CW, Liang GS, Hauser RA, Sudarsky L, Umeh CC, Voss T, Juncos J, Fang JY, Boyd JT, Bodis-Wollner I, Mari Z, Morgan JC, Wills AM, Lee SL, Parashos SA; NINDS NET-PD Investigators. J Neurol Sci. 2017 Jun 15;377:137-143. doi: 10.1016/j.jns.2017.04.011. Epub 2017 Apr 11. PMID: 28477684 PMCID: PMC5518305
    18. Thalamic cholinergic innervation makes a specific bottom-up contribution to signal detection: Evidence from Parkinson's disease patients with defined cholinergic losses.Kim K, Müller ML, Bohnen NI, Sarter M, Lustig C. Neuroimage. 2017 Apr 1;149:295-304. doi: 10.1016/j.neuroimage.2017.02.006. Epub 2017 Feb 5. PMID:28167350  PMCID:PMC5386784
    19. Acetylcholine release in prefrontal cortex promotes gamma oscillations and theta-gamma coupling during cue detection.Howe WM, Gritton HJ, Lusk NA, Roberts EA, Hetrick VL, Berke JD, Sarter M. J Neurosci. 2017 Mar 22;37(12):3215-3230. doi: 10.1523/JNEUROSCI.2737-16.2017. Epub 2017 Feb 17. PMID:28213446.PMCID:PMC5373115
    20. Unresponsive choline transporter as a trait neuromarker and a causal mediator of bottom-up attentional biases.Koshy Cherian A, Kucinski A, Pitchers K, Yegla B, Parikh V, Kim Y, Valuskova P, Gurnani S, Lindsley CW, Blakely RD, Sarter M. J Neurosci. 2017 Mar 15;37(11):2947-2959. doi: 10.1523/JNEUROSCI.3499-16.2017. Epub 2017 Feb 13. PMID:28193693  PMCID:PMC5354335
    21. 2-year natural decline of cardiac sympathetic innervation in idiopathic Parkinson disease studied with 11C-hydroxyephedrine PET.Wong KK, Raffel DM, Bohnen NI, Altinok G, Gilman S, Frey KA. J Nucl Med. 2017 Feb;58(2):326-331. doi: 10.2967/jnumed.116.176891. Epub 2016 Aug 18. PMID:  27539837. PMCID: PMC5288743
    22. Molecular imaging to track Parkinson's disease and atypical parkinsonisms: New imaging frontiers.Strafella AP, Bohnen NI, Perlmutter JS, Eidelberg D, Pavese N, Van Eimeren T, Piccini P, Politis M, Thobois S, Ceravolo R, Higuchi M, Kaasinen V, Masellis M, Peralta MC, Obeso I, Pineda-Pardo JÁ, Cilia R, Ballanger B, Niethammer M, Stoessl JA; IPMDS-Neuroimaging Study Group. Mov Disord. 2017 Feb;32(2):181-192. doi: 10.1002/mds.26907. Epub 2017 Feb 2. Review. PMID: 28150432
    23. What would Dr. James Parkinson think today? Neuroimaging in Parkinson’s Disease. Albin RL. Mov Disord 2017 Feb;32(2):179-180 PMID: 28218459
    24. Impaired contrast sensitivity is associated with more severe cognitive impairment in Parkinson disease. Ridder A, Müller ML, Kotagal V, Frey KA, Albin RL, Bohnen NI. Parkinsonism Relat Disord. 2017 Jan;34:15-19. doi: 10.1016/j.parkreldis.2016.10.006. Epub 2016 Oct 7. PMCID: 5222688
    25. Reducing falls in Parkinson's disease: interactions between donepezil and the 5-HT6 receptor antagonist idalopirdine on falls in a rat model of impaired cognitive control of complex movements.Kucinski A, de Jong IE, Sarter M. Eur J Neurosci. 2017 Jan;45(2):217-231. doi: 10.1111/ejn.13354. Epub 2016 Aug 18. PMID: 27469080
    26. Influence of intracranial air on electrode position and clinical outcomes flowing deep brain stimulation for Parkinson's disease. Bentley JN, Guan Z, Cummings KS, Chou KL, Patil PG. Stereotact Funct Neurosurg. 2017;95(1):6-12. doi: 10.1159/000452843. Epub 2017 Jan 14. PMID:  28088795
    27. Cerebral amyloid burden and Hoehn and Yahr Stage 3 scoring in Parkinson disease.Kotagal V, Bohnen NI, Müller ML, Frey KA, Albin RL. J Parkinsons Dis. 2017;7(1):143-147. doi: 10.3233/JPD-160985. PMID:28106566PMCID: PMC5470115
    28. Translational MRI volumetry with NeuroQuant: Effects of version and normative data on relationships with memory performance in healthy older adults and patients with Mild Cognitive Impairment. Stelmokas J, Yassay L, Giordani B, Dodge HH, Dinov ID, Bhaumik A, Sathian K, Hampstead BM. Journal of Alzheimer’s disease: JAD. 2017;60(4):1499-1510. PubMed PMID: 29060939; PubMed Central PMCID: PMC5858697.
    2016
    1. Cognitive function in 1736 participants in NINDS Exploratory Trials in PD long-term study-1.Wills AA, Elm JJ, Ye R, Chou KL, Parashos SA, Hauser RA, Bodis-Wollner I, Hinson VK, Christine CW, Schneider JS; NINDS NET-PD Investigators. Parkinsonism Relat Disord. 2016 Dec;33:127-133. doi: 10.1016/j.parkreldis.2016.10.005. Epub 2016 Oct 8. PMID: 27743701  PMCID: PMC6091572
    2. T2-imaging changes in the Nigrosome-1 relate to clinical measures of Parkinson's disease.Fu KA, Nathan R, Dinov ID, Li J, Toga AW. Front Neurol. 2016 Oct 20;7:174. eCollection 2016.PMID:27812347 PMCID:PMC5071353
    3. Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.Kett LR, Dauer WT. Mov Disord. 2016 Oct;31(10):1433-1443. doi: 10.1002/mds.26797. PMID:27619535  PMCID:PMC5061051
    4. COMPASS: A computational model to predict changes in MMSE scores 24-months after initial assessment of Alzheimer's disease.Zhu F, Panwar B, Dodge HH, Li H, Hampstead BM, Albin RL, Paulson HL, Guan Y. Sci Rep. 2016 Oct 5;6:34567. doi: 10.1038/srep34567. PMID: 27703197   PMCID:PMC5050516
    5. Orthostatic hypotension predicts motor decline in early Parkinson disease.Kotagal V, Lineback C, Bohnen NI, Albin RL; CALM-PD Parkinson Study Group Investigators..Parkinsonism Relat Disord. 2016 Nov;32:127-129. doi: 10.1016/j.parkreldis.2016.09.011. Epub 2016 Sep 9. PMID:27639815  PMCID:PMC5114666
    6. Predictive big data analytics: A study of Parkinson's disease Using large, complex, heterogeneous, incongruent, multi-source and incomplete observations.Dinov ID, Heavner B, Tang M, Glusman G, Chard K, Darcy M, Madduri R, Pa J, Spino C, Kesselman C, Foster I, Deutsch EW, Price ND, Van Horn JD, Ames J, Clark K, Hood L, Hampstead BM, Dauer W, Toga AW. PLoS One. 2016 Aug 5;11(8):e0157077. doi: 10.1371/journal.pone.0157077. eCollection 2016. PMID:27494614 PMCID:PMC4975403
    7. Comparison of genomic data via statistical distribution.Amiri S, Dinov ID. J Theor Biol. 2016 Oct 21;407:318-27. doi: 10.1016/j.jtbi.2016.07.032. Epub 2016 Jul 25. PMID: 27460589  PMCID:PMC5361063
    8. Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility.Sarter M, Lustig C, Blakely RD, Koshy Cherian A. J Physiol Paris. 2016 Sep;110(1-2):10-18. doi: 10.1016/j.jphysparis.2016.07.001. Epub 2016 Jul 9. Review. PMID:27404793 PMCID: PMC5164965
    9. Motor speech apraxia in a 70-year-old man with left dorsolateral frontal arachnoid cyst: A [18F]FDG PET-CT Study.Bohnen NI, Haugen J, Kluin K, Kotagal V. Case Rep Neurol Med. 2016;2016:8941035. doi: 10.1155/2016/8941035. Epub 2016 Nov 24. PMID: 28003922
    10. Investigation of proposed activity of clarithromycin at GABAA receptors using [(11)C]Flumazenil PET. Scott PJ, Shao X, Desmond TJ, Hockley BG, Sherman P, Quesada CA, Frey KA, Koeppe RA, Kilbourn MR, Bohnen NI. ACS Med Chem Lett. 2016 Jun 1;7(8):746-50. doi: 10.1021/acsmedchemlett.5b00435. eCollection 2016 Aug 11. PMID: 27563397 PMCID:PMC4983726
    11. Reverse translation in Parkinson disease.Albin RL, Frey KA. J Nucl Med. 2016 Oct;57(10):1497-1498. Epub 2016 May 5. No abstract available. PMID:27151982  PMCID:PMC5367440
    12. Diabetes, gray matter loss, and cognition in the setting of Parkinson disease.Petrou M, Davatzikos C, Hsieh M, Foerster BR, Albin RL, Kotagal V, Müller ML, Koeppe RA, Herman WH, Frey KA, Bohnen NI. Acad Radiol. 2016 May;23(5):577-81. doi: 10.1016/j.acra.2015.07.014. PMID: 26874576; PMCID: PMC4859345.
    13. What do phasic cholinergic signals do?Sarter M, Lustig C, Berry AS, Gritton H, Howe WM, Parikh V. Neurobiol Learn Mem. 2016 Apr;130:135-41. doi:10.1016/j.nlm.2016.02.008. Review.PMID: 26911787;PMCID: PMC4818703.
    14. Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation. Haugen J, Müller ML, Kotagal V, Albin RL, Koeppe RA, Scott PJ, Frey KA, Bohnen NI. J Neural Transm (Vienna). 2016 Apr;123(4):421-4. doi: 10.1007/s00702-016-1524-7.PMID: 26911386; PMCID: PMC4805466.
    15. Interactive effects of age and multi-gene profile on motor learning and sensorimotor adaptation.Noohi F, Boyden NB, Kwak Y, Humfleet J, Müller ML, Bohnen NI, Seidler RD. Neuropsychologia. 2016 Apr;84:222-34. doi: 10.1016/j.neuropsychologia.2016.02.021. Epub 2016 Feb 27. PMID:26926580  PMCID: PMC4849282
    16. Methodological challenges and analytic opportunities for modeling and interpreting Big Healthcare Data.Dinov ID. Gigascience. 2016 Feb 25;5:12. doi: 10.1186/s13742-016-0117-6. eCollection 2016. Review.PMID:26918190 : PMCID:PMC4766610
    17. Cortical cholinergic signaling controls the detection of cues.Gritton HJ, Howe WM, Mallory CS, Hetrick VL, Berke JD, Sarter M. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1089-97. doi: 10.1073/pnas.1516134113.PMID: 26787867;PMCID: PMC4776505.
    18. Parkinson's disease-related fatigue: A case definition and recommendations for clinical research.Kluger BM, Herlofson K, Chou KL, Lou JS, Goetz CG, Lang AE, Weintraub D, Friedman J. Mov Disord. 2016 May;31(5):625-31. doi: 10.1002/mds.26511. Epub 2016 Feb 16. Review. PMID: 26879133 PMCID:PMC4863238
    19. Fatigue in Parkinson's disease: report from a mutidisciplinary symposium.Friedman JH, Beck JC, Chou KL, Clark G, Fagundes CP, Goetz CG, Herlofson K, Kluger B, Krupp LB, Lang AE, Lou JS, Marsh L, Newbould A, Weintraub D. NPJ Parkinsons Dis. 2016;2. pii: 15025. Epub 2016 Jan 14. PMID:27239558  PMCID:PMC4883681
    20. Mini-review: Retarding aging in murine genetic models of neurodegeneration.Albin RL, Miller RA. Neurobiol Dis. 2016 Jan;85:73-80. doi:10.1016/j.nbd.2015.10.014. Review. PMID: 26477301 PMCID:PMC4688232.
    21. Striatal and cortical β-amyloidopathy and cognition in Parkinson's disease. Shah N, Frey KA, Müller ML, Petrou M, Kotagal V, Koeppe RA, Scott PJ, Albin RL, Bohnen NI.Mov Disord. 2016 Jan;31(1):111-7. doi: 10.1002/mds.26369.PMID:26380951;PMCID: PMC4724301.
    22. Volume and value of big healthcare data.Dinov ID. J Med Stat Inform. 2016;4. pii: 3.PMID: 26998309;PMCID: PMC4795481.
    23. Neuroimaging and clinical predictors of fatigue in Parkinson disease.Chou KL, Kotagal V, Bohnen NI. Parkinsonism Relat Disord. 2016 Feb;23:45-9. Epub 2015 Dec 2. PMID:26683744  PMCID:PMC4724499
    24. Predicting first fall in newly diagnosed Parkinson’s disease: Insights from a fall-naïve cohort. Beaulieu ML, Müller MLTM, Bohnen NI. Mov Disord. 2016 Dec; 31(12): 1829–1836. Published online 2016 Sep 13. doi: 10.1002/mds.26742 PMCID: PMC5880273
    25. Is PIGD a legitimate motor subtype in Parkinson disease? Kotagal V. Ann Clin Transl Neurol. 2016 May 11;3(6):473-7. doi: 10.1002/acn3.312. PMID: 27547776; PMCID: PMC4892002.
    26. Out of one mutation, many Huntington's disease effects. Albin RL. Lancet Neurol. 2015 Nov;14(11):1071-2. doi: 10.1016/S1474-4422(15)00247-1. PMID: 26466773.
    2015
    1. Big biomedical data as the key resource for discovery science. Toga AW, Foster I, Kesselman C, Madduri R, Chard K, Deutsch EW, Price ND, Glusman G, Heavner BD, Dinov ID, Ames J, Van Horn J, Kramer R, Hood L. J Am Med Inform Assoc. 2015 Nov;22(6):1126-31. Epub 2015 Jul 21.PMID:26198305 PMCID:PMC5009918
    2. Post-Mortem evaluation of amyloid-dopamine terminal positron emission tomography dementia classifications.Albin RL, Fisher-Hubbard A, Shanmugasundaram K, Koeppe RA, Burke JF, Camelo-Piragua S, Lieberman AP, Giordani B, Frey KA. .Ann Neurol. 2015 Nov;78(5):824-30. doi: 10.1002/ana.24481. PMID: 26183692; PMCID: PMC4836870.
    3. Non-exercise physical activity attenuates motor symptoms in Parkinson disease independent from nigrostriatal degeneration.Snider J, Müller ML, Kotagal V, Koeppe RA, Scott PJ, Frey KA, Albin RL, Bohnen NI. Parkinsonism Relat Disord. 2015 Oct;21(10):1227-31. doi: 10.1016/j.parkreldis.2015.08.027. PMID:26330028; PMCID: PMC4587298.
    4. Behavioral-cognitive targets for cholinergic enhancement.Sarter M. Current opinion in behavioral sciences. 2015 August;4:22-26. PubMed PMID: 28607947; PubMed Central PMCID: PMC5466806
    5. Educational attainment and motor burden in Parkinson disease.Kotagal V, Bohnen NI, Müller ML, Koeppe RA, Frey KA, Langa KM, Albin RL.Mov Disord. 2015 Jul;30(8):1143-7. doi: 10.1002/mds.26272. PMID: 26096339;  PMCID: PMC4504749.
    6. Sharing big biomedical data.Toga AW, Dinov ID. J Big Data. 2015;2. pii: 7. Epub 2015 Jun 27. PMID:26929900 PMCID: PMC4768816
    7. Probability distributome: A web computational infrastructure for exploring the properties, interrelations, and applications of probability distributions. Dinov ID, Siegrist K, Pearl DK, Kalinin A, Christou N. Comput Stat. 2016 Jun;31(2):559-577. Epub 2015 Jun 26. PMID:27158191 PMCID: PMC4856044
    8. Amyloid deposition in Parkinson's disease and cognitive impairment: A systematic review.Petrou M, Dwamena BA, Foerster BR, MacEachern MP, Bohnen NI, Müller ML, Albin RL, Frey KA. Movement Disorders. Mov Disord. 2015 Jun;30(7):928-35. doi: 10.1002/mds.26191. PMID: 25879534 PMCID: PMC4478091
    9. Altered cerebellar connectivity in Parkinson's patients ON and OFF L-DOPA medication.Festini SB, Bernard JA, Kwak Y, Peltier S, Bohnen NI, Müller ML, Dayalu P, Seidler RD. Front Hum Neurosci. 2015 Apr 21;9:214. doi: 10.3389/fnhum.2015.00214. eCollection 2015. PMID:25954184  PMCID:PMC4405615
    10. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.Kett LR, Stiller B, Bernath MM, Tasset I, Blesa J, Jackson-Lewis V, Chan RB, Zhou B, Di Paolo G, Przedborski S, Cuervo AM, Dauer WT. J Neurosci. 2015 Apr 8;35(14):5724-42. doi: 10.1523/JNEUROSCI.0632-14.2015. PMID: 25855184; PMCID:PMC4388928.
    11. Modeling falls in Parkinson’s disease: Slow gait, freezing episodes, and falls in rats with extensive striatal dopamine loss.Kucinski A, Albin RL, Lustig C, Sarter M. Behav Brain Res. 2015 Apr 1;282:155-64. doi:10.1016/j.bbr.2015.01.012.PMID: 25595423; PMCID:PMC4323874.
    12. Modeling Parkinson’s disease falls associated with brainstem cholinergic systems decline. Kucinski A, Sarter M. Behav Neurosci. 2015 Apr;129(2):96-104. doi: 10.1037/bne0000048.PMID: 25798629; PMCID: PMC4392884.
    13. Neuroimaging of freezing of gait. Fasano A, Herman T, Tessitore A, Strafella AP, Bohnen NI. J Parkinsons Dis. 2015;5(2):241-54. doi: 10.3233/JPD-150536. Review. PMID: 25757831 PMCID:PMC4923721
    14. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators., Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB Jr, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM. JAMA. 2015 Feb 10;313(6):584-93.PMID:25668262  PMCID:PMC4349346
    15. Clinical markers for identifying cholinergic deficits in Parkinson's disease.Müller ML, Bohnen NI, Kotagal V, Scott PJ, Koeppe RA, Frey KA, Albin RL. Mov Disord. 2015 Feb;30(2):269-73. doi: 10.1002/mds.26061. PMID: 25393613; PMCID: PMC4318774.
    16. Interpreting chemical neurotransmission in vivo: techniques, time scales, and theories. Sarter M, Kim Y. ACS Chem Neurosci. 2015 Jan 21;6(1):8-10. doi:10.1021/cn500319m. Review.PMID: 25514622;PMCID:PMC4304491.
    17. Gene interactions and structural brain change in early-onset Alzheimer's disease subjects using the pipeline environment.Moon SW, Dinov ID, Zamanyan A, Shi R, Genco A, Hobel S, Thompson PM, Toga AW; Alzheimer's Disease Neuroimaging Initiative (ADNI). Psychiatry Investig. 2015 Jan;12(1):125-35. doi:10.4306/pi.2015.12.1.125.PMID: 25670955; PMCID:PMC4310910.
    18. Validation of an ambulatory capacity measure in Parkinson disease: a construct derived from the Unified Parkinson's Disease Rating Scale.Parashos SA, Elm J, Boyd JT, Chou KL, Dai L, Mari Z, Morgan JC, Sudarsky L, Wielinski CL. J Parkinsons Dis. 2015;5(1):67-73. doi: 10.3233/JPD-140405.PMID:25311202 PMCID:PMC4478048
    19. SOCR data dashboard: an integrated big data archive mashing medicare, labor, census and econometric information.Husain SS, Kalinin A, Truong A, Dinov ID. J Big Data. 2015;2. pii: 13.PMID:26236573 PMCID: PMC4520712
    20. Structural Neuroimaging Genetics Interactions in Alzheimer's Disease.Moon SW, Dinov ID, Kim J, Zamanyan A, Hobel S, Thompson PM, Toga AW. J Alzheimers Dis. 2015;48(4):1051-63. doi: 10.3233/JAD-150335.PMID: 26444770; PMCID: PMC4730943.
    21. Cholinergic capacity mediates prefrontal engagement during challenges to attention: evidence from imaging genetics.Berry AS, Blakely RD, Sarter M, Lustig C. Neuroimage. 2015 Mar;108:386-95. doi: 10.1016/j.neuroimage.2014.12.036. Epub 2014 Dec 20. PMID:25536497  PMCID:PMC4469545
    22. Potential trade-offs in treatment of premanifest Huntington's disease. Albin RL, Burke JF. Mov Disord. 2015 Sep;30(10):1319-23. doi: 10.1002/mds.26318. Epub 2015 Jul 14. PMID: 26173644; PMCID: PMC4873710.
    23. Structural brain changes in early-onset Alzheimer's disease subjects using the LONI pipeline environment. Moon SW, Dinov ID, Hobel S, Zamanyan A, Choi YC, Shi R, Thompson PM, Toga AW; Alzheimer's Disease Neuroimaging Initiative. J Neuroimaging. 2015 Sep-Oct;25(5):728-37. doi: 10.1111/jon.12252. Epub 2015 May 4. PMID: 25940587; PMCID: PMC4537660.
    2014
    1. Modeling test and treatment strategies for presymptomatic Alzheimer Disease.Burke JF, Langa KM, Hayward RA, Albin RL. PLoS One. 2014 Dec 4;9(12):e114339.PMID: 25474698; PMCID: PMC4256252.
    2. Deterministic functions of cortical acetylcholine. Sarter M, Lustig C, Howe WM, Gritton H, Berry AS. Eur J Neurosci. 2014 Jun;39(11):1912-20. doi: 10.1111/ejn.12515. Epub 2014 Mar 4. Review. PMID: 24593677 PMCID: PMC4371531
    3. Where attention falls: Increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function. Sarter M, Albin RL, Kucinski A, Lustig C. Exp Neurol. 2014 Jul;257:120-9. doi: 10.1016/j.expneurol.2014.04.032. Epub 2014 May 5. Review. PMID:  24805070  PMCID: PMC4348073
    4. Abnormal MoCA and normal range MMSE scores in Parkinson disease without dementia: cognitive and neurochemical correlates. Chou KL, Lenhart A, Koeppe RA, Bohnen NI. Parkinsonism Relat Disord. 2014 Oct;20(10):1076-80. doi: 10.1016/j.parkreldis.2014.07.008. Epub 2014 Jul 19. PMID:  25085750 PMCID: PMC4180768
    5. Validity and efficacy of screening algorithms for assessing Deep Brain Stimulation Candidacy in Parkinson disease. Coleman RR, Kotagal V, Patil PG, Chou KL. Mov Disord Clin Pract. 2014 Dec 1;1(4):342-347. PMID: 25505791 PMCID:PMC4258408

  • Project I:  Evolution of cholinergic deficits within multisensory, cognitive, and motor integration brain regions and development of PIGD features in people with Parkinson’s disease

    PI: Nicolaas Bohnen MD, PhD

    [18F]FEOBV PET delineates specific cortical regions and deep brain structures, including striatum and thalamic subnuclei. PD subjects with falls vs those with falls and gait freezing exhibit distinct abnormal patterns, highlighted by reduced striatal [18F]FEOBV as a shared dysfunctional node. Dr. Bohnen and his team will prospectively test the hypothesis that the cholinergic AMI network dysfunctions they describe are core features of PD gait and balance dysfunction, and that distinct patterns of cholinergic pathology predict specific features of PD gait dysfunction. The serial assessments proposed will allow unique within-subject analysis for the temporal dissection of distinct and converging elements of mobility control deficits of gait-balance motor features in PD. Unlike the prior grant cycle where longitudinal assessment was limited, esp. for PwP converting from non-fallers/freezers to fallers/freezers, the current cycle will allow clinically meaningful follow-up assessments of up to 5-6 years of PwP who completed baseline [18F]FEOBV PET. Hypotheses to test: 1) whether incident fallers exhibit [18F]FEOBV defects in the caudate, visual thalamus, and prefrontal cortex (compared to non-converters), and 2) whether the subsequent emergence of gait freezing involves additional and more widespread cholinergic vulnerability of the striatum, limbic archicortex, including the cingulo-opercular and insular cortices. The existence of the unique PD subject cohort developed in the currently funded cycle, together with newly recruited subjects, will allow study of an enriched sample of those converting to falls and/or to gait freezing. The focus on visual thalamus, based on the repeated association of falls with cholinergic dysfunction (found with both [11C]PMP and [18F]FEOBV), is another important and novel element. Many thalamic nuclei are primarily interconnected with association cortices with these thalamic nuclei are increasingly viewed as partners and/or modulators of cortical functions. Emerging evidence supports critical roles of visual thalamus in mediating visual attention. LGN function is modulated by attention, indicating a key role for this relay structure in bottom-up attention. Dr. Bohnen has new data implicating cholinergic denervation of additional regions driving non-episodic PIGD deficits preceding falls and FoG. This data indicates that cholinergic deficits within the MGN and entorhinal cortex (EC) are robustly associated with non-episodic PIGD, independent of nigrostriatal dopaminergic deficits. MGN is involved in processing multi-sensory (auditory, vestibular and proprioceptive) inputs, implying a significant role of impaired sensorimotor integration underlying early PIGD features in PwP. EC is associated with visuospatial maps, suggesting deficient attention-visuomotor integration.  Complementary work will be performed in the Catalyst Research Project. The analysis of cholinergic system changes of the evolution of balance and gait disturbances will be complemented by exploratory mechanistic multisensory and attentional-motor integration studies.  These studies will identify the key patterns of cholinergic systems dysfunction underlying treatment-refractory gait and balance disorders in PwP.

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    Project II: Circuit Mechanisms of Attentional-Motor Interface Dysfunction in PD Falls

    PI: Kent Berridge, PhD (replacing Martin Sarter, PhD)

    This project builds on Dr. Martin Sarter’s published and preliminary work dissecting the mechanisms of the detection of relevant cues, transfer of this information to striatum, and its integration with ongoing motor processing. Based on the Sarter team’s demonstration of a role for basal forebrain cholinergic projections in the DL (dual lesion) rodent model of PD falling, this project uses optogenetic techniques to test the hypothesis that an enhanced fall propensity can be caused specifically by the loss of fast cholinergic signaling (i.e., “transients”) known to mediate attention. Additional experiments define how cholinergic-mediated cortical attentional information is integrated with motor selection processes. Frontostriatal circuitry (glutamatergic corticostriatal projections) is essential for action planning, particularly when habit-guided action is disrupted and task shifts are needed. Such adjustment depends critically on corticostriatal information transfer to guide adaptive movement selection and sequencing. Deficient cortical cholinergic activity impairs attentional shifts toward alternative actions, uncoupling striatal action selection from goals, causing ill-timed or absent responses. Guided by this framework, intrinsic to the AMI model, Dr. Sarter’s team acquired compelling preliminary data detecting the signals encoding attentional information transferred to the striatum (via corticostriatal terminals), where it is hypothesized to be integrated with vigor and kinematic signals supplied by nigrostriatal dopaminergic terminals. Utilizing a novel behavioral paradigm, they demonstrate that a cue instructing the animal to turn evokes a time-locked increase of striatal glutamate (that will be shown to originate from corticostriatal afferents), and a similarly timed burst of acetylcholine from cholinergic neurons. Dr. Sarter’s former team, now under the direction of Dr. Berridge, is specifically testing the hypothesis that this integrative function is essential for complex motor control, including PD gait dysfunction. Preliminary findings strongly support a role for cholinergic signals in integrating the attentional and motor signals during gait; chemogenetic activation of these neurons reduces fall propensity in DL rats (often preceded by freezing-like motor behaviors in the animals), whereas their inhibition in intact animals mimics DL-type falls. These data support key aspects of the AMI model by implicating cholinergic neurotransmission at two successive nodes along the cortico-striatal pathway critical to support the attentional-motor interface – in cortex for signal detection, and in striatum for signal integration. These studies will identify key substrates of attentional-motor integration in the AMI.

    .

    Project III: Cingulo-Opercular Task Control Network Cholinergic Dysfunction in PD

    PIs: Roger L Albin, MD 

    Our preliminary results indicate a global effect of key AMI node AC-I cholinergic denervation on cognitive functions. These cortical regions are key nodes of the COTC network and participate in higher level aspects of attentional function. We will confirm that AC-I denervation is associated with widespread cognitive deficits. Our established PD cohort, extensively characterized with dopaminergic and cholinergic PET, and with motor and cognitive assays, uniquely positions us to define the distinctive natural history of a PD subgroup based on a pathologic marker. Continued follow-up of this valuable cohort will assess if AC-I cholinergic denervation predicts significantly greater global cognitive decline. Quantification of cholinergic changes in the COTC subcortical and cortical (AC-I) network in this cohort will also allow the assessment that progressive cognitive changes coincide with more severe motor changes (aggressive or ‘malignant’ PD subtype). PET studies are costly and [18F]FEOBV is only operational in a handful of centers. A convenient, reliable predictor of AC-I cholinergic denervation is required to employ this phenotype as subgroup marker or stratifying method. We will capitalize on the thorough phenotyping of our cohort and apply more convenient MRI methods, complementing Project I analyses, to explore an accessible biomarker. Through collaboration with investigators at the University of Groningen (Netherlands), we have access to a similarly characterized and prospectively followed cohort of incident PD subjects who also undergo [18F]FEOBV PET. These subjects are part of the Dutch Parkinson and Cognition Study (DUPARC). This collaboration will enable us to rigorously test our hypotheses regarding the impacts and prognostic potential of AC-I cholinergic denervation and identification of a useful predictor in an independent replication cohort. Our Groningen colleagues agreed to share all phenotypic, MRI, and [18F]FEOBV imaging data to address, in parallel, the hypotheses driving Project III.  These studies will identify a key substrate of cognitive impairments and predictor of more rapid cognitive decline in PwP.

    .

    Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration Dysfunction

    PI: Omar Ahmed, PhD

    Many PwP experience DRT-refractory spatial disorientation with inability to integrate external landmark cues with internal estimates of orientation.  The retrosplenial cortex (RSC) is critical for this function with fMRI studies indicating abnormal attentional information processing in PwP.  RSC, an integral AMI component, is densely interconnected with other AMI nodes, the cingulate cortex and anterior thalamus (locus of head position neurons), and receives dense BF cholinergic afferents.  These cholinergic inputs are critical for attentive spatial navigation. In work funded by a U-M Udall Center Pilot Project, Dr. Ahmed uncovered a unique pattern of local inhibition in the RSC. In this Catalyst Research Project, Dr. Ahmed will evaluate the hypotheses that thalamic input mediated spatial information is modulated by BF cholinergic afferents and that cholinergic receptor mediated responses in RSC neurons are critical for maintaining attentive navigation.  RSC inter-hemispheric communication is necessary to maintain attentive navigation.  Dr. Ahmed specifically hypotheses that cholinergic signaling is necessary for normal inter-hemispheric RSC function.  Dr. Ahmed will evaluate these hypotheses in both normal animals and in the dual lesion (DL) model of combined striatal dopaminergic denervation and cortical cholinergic denervation developed by Dr. Sarter.  This study will identify mechanisms of information transfer within a key AMI node. These experiments provide a cellular level examination of cholinergic functions within an AMI node, complementing the systems and circuit level approaches of the other projects.  The focus on attentive spatial navigation also complements Project I studies assessing the roles of deficient sensorimotor and visuomotor integration in PwP.

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  • Join a Study

    Now is the time to join our research team. Research participation is a generous gift – a gift that can be shared with future generations as we pave the way to new discoveries in treatment and prevention. Research participation contributes to the discovery of new ways to diagnose, treat and support people with Parkinson’s disease.

    If you are interested in joining a particular study, please contact the study coordinator listed.

    MHealth Research allows patients to learn about some of our current research studies. Just type in a diagnosis in the search box (for example, Parkinson’s disease) and then the list of studies that are currently using this site will pop-up.

    For a complete list of research studies, see below:

     

    Parkinson’s Disease Clinical Research Studies

     

    Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Tributyrin supplementation (PI: Bohnen/Albin)

    Objective: To explore glucose metabolism, clinical measures, and [11C]butyrate and [18F]FDG PET imaging before and after open-label treatment using the small chain fatty acid (SCFA) prodrug, tributyrin, in a small pilot study in patients with PD and healthy older adults.

    Inclusion Criteria:

    1. Healthy control persons
      1. Age 45 years and above (M/F)
      2. Without history of neurological or psychiatric disease, significant GI disease, or uncontrolled medical comorbidity
    2. Parkinson’s disease (PD)
      1. Diagnosis of PD based on the United Kingdom Parkinson’s Disease Society Brain Bank Diagnostic Research Criteria
      2. M/F, age 45 years and over

    Exclusion criteria:

    1. Exclusion:
      1. Subjects with contra-indications to MR imaging, including pacemakers or claustrophobia
      2. Evidence of large vessel stroke or mass lesion on MRI
      3. Regular use of anti-cholinergic, benzodiazepines or neuroleptic drugs
      4. history of significant GI disease
      5. significant metabolic or uncontrolled medical comorbidity
      6. poorly controlled diabetes
      7. pregnancy or breast feeding
      8. dementia requiring informed assent
      9. suicidal ideation

    Coordinator: Alexis Griggs, gralexis@med.umich.edu; Robert Vangel rvangel@med.umich.edu.

    Causal examinations of the attention-motor interface in gait and falls (PI: Lee/Albin)

    Objective: This study will explore how the brain areas important for attention and short-term memory might be contributing to some of the movement issues seen in persons with Parkinson’s Disease. Sessions will involve magnetic resonance imaging (MRI) and transcranial magnetic stimulation (TMS).

    Inclusion criteria:

    1. Parkinson disease (PD) with PD diagnosis based on the recent Movement Disorder Society criteria.
    2. PD subjects >45 years and <91 will be studied.
    3. H&Y1-2 (early PD) subjects will be recruited.
    4. Only PD subjects on stable dopamine replacement therapy will be recruited.

     

    Exclusion criteria:

    1. The presence of other neurologic disease or neurologic findings on examination.
    2. Depression: Geriatric Depression Scale (GDS) score >11.
    3. Evidence of a stroke or mass lesion on prior structural brain imaging (CT or MRI).
    4. Evidence of any confounding medical or psychiatric problem that would preclude task participation.
    5. Metallic medical implants (i.e. pacemaker), foreign objects in body, non-removable body-piercings
    6. Pregnancy

    Additional exclusion criteria related to TMS:

    • Metal in the cranium (mouth excluded)
    • Cardiac pacemaker
    • Implanted medication pump
    • Implanted deep brain stimulator or vagus nerve stimulator
    • Intracardiac lines
    • Serious heart disease
    • Increased intracranial pressure
    • History of seizures
    • Epileptogenic medication
    • Cochlear implants
    • Recent extended air travel resulting in jetlag or other sleep deprived state

    Coordinator: Teresa Scerbak tescerba@med.umich.edu

     

    Cholinergic mechanisms of attentional-motor integration and gait dysfunction in Parkinson Disease. The Morris K. Udall Center of Excellence for Parkinson’s Disease Research. (PI: Bohnen)

    Objective:  Advance our understanding of progressive cholinergic changes within specific subcortical and cortical structures subserving cognitive and attentional-motor integration functions in PwP at risk of dementia, balance and gait disturbances.

    Inclusion Criteria:

    1. Age 45 and above (M/F).
    2. PD diagnosis (with or without Mild Cognitive Impairment) will follow the Movement Disorder Society-revised clinical diagnostic criteria for PD (7). Absence of dementia confirmed by neuropsychological testing. Modified Hoehn and Yahr stages 1-4 (8, 9).
    3. All PD subjects are required to have nigrostriatal dopaminergic denervation as demonstrated by vesicular monoaminergic transporter type-2 (VMAT) [11C]DTBZ positron emission tomography (PET) imaging. This may be based on a prior DTBZ PET scan or the DTBZ PET scan performed as part of this study.

     

    Exclusion Criteria:

    1. Presence of clinically significant dementia.
    2. Disorders which may resemble PD, such as dementia with Lewy bodies, vascu­lar dementia, normal pressure hydrocephalus, multiple system atrophy, corticobasal ganglionic dege­neration, or toxic causes of parkinsonism. The use of the Movement Disorder Society-revised clinical diagnostic criteria will mitigate the inclusion of PD subjects with atypical parkinsonism.
    3. Subjects on neuroleptic, anticholinergic (trihexiphenidyl, benztropine), or cholinesterase inhibitor drugs. Subjects with prior exposure to disallowed medications may be eligible if there has been an interval of > 2 months off these medications.
    4. Evidence of a large vessel stroke in a clinically relevant area (cerebral cortex, basal ganglia, thalamus) or mass lesion on structural brain imaging (MRI or CT).
    5. Participants in whom MRI is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant.
    6. Severe claustrophobia precluding MR or PET imaging.
    7. Subjects limited by previous participation in research procedures involving ionizing radiation.
    8. Pregnancy (test within 48 hours of each PET session) or breastfeeding.
    9. History of deep brain stimulation surgery.
    10. Suicidality (responses 2 or 3 for question 9 on the Beck Depression Inventory).

     

    Coordinator:  Fotini Michalakis fotinim@med.umich.edu

     

    The Thalamus in Parkinson Disease (PIs: Albin/Bohnen)

    Objective: To understand the role of thalamus dysfunction in Parkinson disease.  This study involves brain imaging studies of important brain chemical messengers, and careful characterization of motor and cognitive functions.

    Inclusion Criteria:

    • Age 45 and above, Male or Female.
    • PD diagnosis (with or without mild cognitive impairment).
    • All PD subjects will be required to have nigrostriatal dopaminergic denervation as demonstrated by PET scan.

     

    Exclusion Criteria:

    • Presence of significant dementia.
    • Disorders which may resemble PD, such as dementia with Lewy bodies, vascular dementia, normal pressure hydrocephalus, multiple system atrophy, corticobasal ganglionic degeneration, or toxic causes of parkinsonism.
    • Subjects on neuroleptic (except for low dose quetiapine 25-50 mg/d), anticholinergic (trihexiphenidyl, benztropine), cholinesterase inhibitors. Subjects with prior exposure to disallowed medications may be eligible if there has been an interval of greater than 2 months and/or 5 times their plasma half-life off these medications.
    • Evidence of a large vessel stroke in a clinically relevant or mass lesion on structural brain imaging.
    • Participants in whom magnetic resonance imaging (MRI) is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant.
    • Severe claustrophobia.
    • Subjects limited by previous participation in research procedures involving radiation. Pregnancy (test within 48 hours of each PET session) or breastfeeding.
    • History of deep brain stimulation surgery.
    • Subjects with primary ophthalmological disorders, such as glaucoma, resulting in poor vision (corrected vision OU < 0.2). 

    .

    Coordinator:  Jacqueline Caswell: jlcaswel@med.umich.edu

    .

    PPMI 2.0 (PI: Chou)

    Objective: to continue to obtain information from people with and without Parkinson disease so that researchers may better understand how PD progresses, in order to inform better treatments.  Study procedures include DaTscan, MRI, Lumbar puncture and skin biopsy.

    Inclusion Criteria:

    • 30+ years old
    • PD diagnosed w/in 2 years
    • Not expected to require PD medication within at least 6 months from Baseline
    • Must have at least two of the following: resting tremor, bradykinesia, rigidity (must have either resting tremor or bradykinesia); OR either asymmetric resting tremor or asymmetric bradykinesia
    • Hoehn and Yahr stage I or II
    • Confirmation that participant is eligible based on Screening DaTscan imaging
    • Treatment naive

    .

    Exclusion:

    • Currently taking levodopa, dopamine agonists, MAO-B inhibitors, amantadine or another PD medication.
    • Has taken levodopa, dopamine agonists, MAO-B inhibitors or amantadine within 60 days of Baseline visit.
    • Received any of the following drugs: dopamine receptor blockers, metoclopramide and reserpine within 6 months of Screening visit.
    • A clinical diagnosis of dementia
    • Previously obtained MRI scan with evidence of clinically significant neurological disorder
    • Current treatment with anticoagulants that might preclude safe completion of the lumbar puncture.

    .

    Coordinator:, Frank Ferrari frankfer@med.umich.edu; Teresa Scerbak tescerba@med.umich.edu; Angela Stovall astovall@med.umich.edu

     

    Vigor and the LDR in Parkinson Disease (PI: Albin)

    Objective: To explore how levodopa treatment in PD produces the Long Duration Response (LDR).

    Inclusion Criteria:

    • PD diagnosis
    • Previously untreated
    • H&Y I or II
    • Age >45 and <81

    .

    Exclusion Criteria:

    • Presence of other neurologic disease or findings on examination
    • Cognitive impairment: MoCA score of <24
    • Depression: GDS score of >5
    • Use of dopamine agonists or stimulants
    • Evidence of a stroke or mass lesion on prior structural brain imaging (MRI or CT)
    • Evidence of any confounding medical or psychiatric problem that would preclude task participation

    .

    Procedures:

    • Demographic Data
    • Clinical Rating Scales: UPDRS, PD-CRS, GDS, Lille Apathy Scale, etc.
    • Simple Tests of Motor Function, Motivational Function

    .

    Coordinator: Teresa Scerbak tescerba@med.umich.edu 

     

    Citalopram in PD (PI: Kotagal)

    Objective: To evaluate the ability of citalopram to alter progression of visuospatial cognitive decline and amyloid-beta plaque deposition in Parkinson disease. A subject will be enrolled for 28 months and will have study visits approximately every 3 months.

    Inclusion Criteria:

    • 65 years of age and older
    • Diagnosis of Parkinson’s Disease, Hoehn and Yahr stage 2-3
    • No current dementia
    • Not currently on an SSRI, SNRI, or TCA

    .

    Exclusion:

    • Active Depression (GDS of 10/30 or greater)
    • Prolonged QTc interval on EKG
    • Contraindications for Brain MRI or PET imaging

    .

    Coordinators: Cate Lewis cathlewi@med.umich.edu; Emily Herreshoff egalopin@med.umich.edu

     

    Web-based Automated Imaging Differentiation of Parkinsonism (PSG/U01 Site-PI: Bohnen)

    Objective: To evaluate diagnostic performance of free water MR imaging to help with the differential diagnosis of atypical parkinsonism.

    Inclusion Criteria:

    • Possible/probable MSA-P
    • Possible probable PSP

    .

    Exclusion:

    • Contra-indication to MRI
    • Claustrophobia
    • Pregnant or nursing women

    .

    Coordinator: Jacqueline Casewell: jlcaswel@med.umich.edu; Diane Wisnieski, LMSW: dmschne@med.umich.edu

     

    SPARX3: Study In Parkinson Disease of Exercise Phase 3 Clinical Trial (PI: Haus)

    Objective: to learn more about the effects of aerobic exercise on people with Parkinson’s disease who have not yet started medication for their PD. It will compare the effects of moderate intensity (60-65% HRmax) treadmill exercise to high intensity (80-85% HRmax) treadmill exercise on the signs and symptoms of Parkinson’s disease.

     

    Inclusion criteria:

    1. Primary Parkinson’s Disease diagnosed using UK Brain Bank Criteria (< 3 years since diagnosis)
    2. Age 40-80 years
    3. Hoehn and Yahr stage less than 3

    Exclusion criteria:

    1. Currently treated with dopaminergic therapies or expected to require such treatment within next 6 months
    2. Use of PD medication within past 60 days
    3. Poorly controlled or unstable cardiovascular, metabolic, or renal disease
    4. Hypertension, hypo- or hyperthyroidism, and/or abnormal renal function. Orthostatic hypotension & standing systolic BP < 100
    5. Disorders that interfere with ability to perform endurance exercises
    6. >120 minutes/week moderate intensity endurance exercise for more than 6 months
    7. MoCA score <26, BDI score >16
    8. Prior SPECT scan within past 6 months
    9. Allergy to iodinated products/hypersensitivity to DaTscan™ SPECT
    10. Women who are pregnant or plan to become pregnant in next 12 months

    Coordinator: Kendell Lewis kenlewis@umich.edu (734) 647-2706

     

    For Parkinson’s Disease/Dementia with Lewy Bodies

    Differentiation of Parkinsonism (PI: Kanel)

    Objective:

    The objective is to perform FEOBV PET imaging in patients with atypical parkinsonian syndromes (APS) such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), and compare cholinergic system changes between the different APS.

    Inclusion criteria:

    • Age 50 and above, Male or Female.
    • DLB patients that meet the Fourth consensus report of the DLB Consortium inclusion criteria for probable DLB.
    • MSA and PSP subjects with a possible or probable diagnosis.

    Exclusion criteria:

    • Subjects with contra-indications to MR imaging, including pacemakers or claustrophobia,
    • Evidence of large vessel stroke or mass lesion on MRI,
    • Use of anti-cholinergic or neuroleptic drugs,
    • Major psychiatric illness, such as bipolar disorder,
    • pregnancy, 
    • Neurological conditions such as epilepsy, stroke, multiple sclerosis, or moderate to severe brain injury
    • Sensory impairments that significantly limit one’s ability to see or hear,
    • significant history of recent alcohol or drug dependence,
    • Previous major radiation exposure.

    Coordinator: Jaimie Barr jaimieba@med.umich.edu

     

    Stimulation of the Cingulo-opercular Alertness Network in LBD (SCAN)

    Objective: To better understand the effects of transcranial direct current stimulation (tDCS) for improving alertness in Lewy Body dementia or Parkinson’s Disease dementia.

    Inclusion Criteria:

    • Age 50 to 90 years
    • Diagnosis of DLB with cognitive fluctuations or PDD
    • Currently on a stable dose of cholinesterase inhibitors

    Diagnoses:

    • PDD: dementia with established PD diagnosis using UKPDSBRC criteria
    • Probable DLB: dementia with two of the following: cognitive fluctuations, visual hallucinations, parkinsonism, abnormal DATscan, RBD

    Exclusion Criteria:

    • History of conditions like stroke, epilepsy, multiple sclerosis, or severe brain injury
    • Contraindication to MRI or tDCS
    • Currently taking neuroleptics

    Coordinator: Isha Ghosh isghosh@med.umich.edu; Diane Wisnieski, LMSW: dmschne@med.umich.edu

     

    Lewy Body Dementia Biomarkers (PI: Frey)

    Objective: To identify protein accumulations in the brain in patients with PD-related dementia using brain imaging (PET and MRI). The study is also part of the Parkinson’s Disease Biomarker Program (PDBP) and will involve annual MDS-UPDRS exams, cognitive testing, and the collection of biofluid samples that will become part of a national data repository. Participation lasts up to 5 years.

    Inclusion Criteria:

    • Age 55 years and older.
    • Dementia (DSM- defined cognitive impairment that impairs working, social interactions or ADLs)
    • MMSE > 16

    Diagnoses

    • PDD: dementia with established PD diagnosis using UKPDSBRC criteria
    • Probable DLB: dementia with twoof: cognitive fluctuations, visual hallucinations, parkinsonism, abnormal DATscan, RBD
    • Possible DLB: dementia with any one of the above features

    Exclusion Criteria:

    • Significant neurological or psychiatric conditions, other than PDD or DLB.
    • Contraindication to MRI
    • Neuroleptics other than quetiapine

    Coordinator: Isha Ghosh isghosh@med.umich.edu; Diane Wisnieski, LMSW: dmschne@med.umich.edu

     

    For Huntington’s Disease

     

    CT-AMT-130-01 (Dayalu)

    A Phase I/II, Randomized, Double-blind, Sham Control Study to Explore Safety, Tolerability, and Efficacy Signals of Multiple Ascending Doses of Striatally-Administered rAAV5-miHTT Total Huntingtin Gene (HTT) Lowering Therapy (AMT-130) in Early Manifest Huntington Disease

    Objective: demonstrate safety and tolerability of AMT-130 when delivered directly to the brain by evaluating changes in safety parameters out to 5 years post AMT-130 treatment in genetically confirmed, early manifest HD patients.

    Inclusion Criteria:

    • 25-65 years of age
    • Clinical diagnosis of early manifest HD
    • Total Functional Capacity Score (TFC) 9-13
    • Diagnosis Confidence Level (DCL) 4 or
    • DCL of 3 with either a positive (“Yes”) response to the UHDRS Question 80 (multidimensional manifest diagnosis on motor, cognitive, behavioral, functional) or DSM5 criteria for cognitive disorder
    • CAG repeat ≥ 40
    • HD con meds stable for 3 months prior to screening
    • Putamen volume of ≥2.5 cm3 (per side) and a caudate volume of ≥2.0 cm3 (per side) on MRI

    .

    Exclusion Criteria:

    • Suicidal risk
    • Contraindication to MRI or LP
    • Malignancy in past 5 years
    • History of gene therapy
    • Significant neurologic comorbid disorder or brain and spinal pathology that may interfere with the surgical delivery of AMT-130

    .

    Coordinator: Angela Stovall astovall@med.umich.edu

     

    Real-time Assessment of Chorea in Persons with Huntington Disease (PI: Carlozzi)

    Objective: To examine the role of chorea in the day-to-day experience of symptoms (sleep, fatigue and anxiety) and functioning (including physical activity and social participation) in individuals with HD using ecological momentary assessment (EMA) and daily diary methodology.

    Inclusion Criteria:

    • Be at least 18 years old
    • Have either a positive gene test for HD and/or have a clinical diagnosis of HD
    • Be able to read, speak, and understand English
    • Be able to provide informed consent
    • Be able to operate the PRO-Diary wrist-worn device independently or have someone who can assist with its operation (putting the watch on/off, silencing alerts, entering the EMA ratings, etc.)
    • Be willing to complete all study assessments, including wearing the PRO-Diary 24 hours/day during the 7-day home monitoring period, except for when bathing/showering/swimming.
    .

    Exclusion:

    • Self-reported neurological insult (epilepsy or seizure disorder, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease/other dementia, stroke, traumatic brain injury, or brain tumor)
    • Anything that would preclude safe or meaningful participation in the study
    .

    Coordinator: Aadi Nalla aanalla@med.umich.edu

     

    ENROLL-HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort (PIs: Carlozzi & Dayalu)

    Objective: Worldwide longitudinal observational study of Huntington’s disease (HD) whose overarching goal is to accelerate progress towards the development of effective therapeutics for HD

    Inclusion Criteria:

    • Carriers:
      • Individuals who carry the HD gene expansion mutation (stage 1 and 2 only)
    • Controls:
      • Individuals who do not carry the HD expansion mutation
        • First or second degree relatives to a carrier;
        • Family members or individuals not related by blood to carriers (e.g. spouses, caregivers); or
        • Community controls, which are individuals unrelated to HD carriers who did not grow up in a family affected by HD
    .

    Exclusion Criteria:

    • Individuals with choreic movement disorders in the context of a negative test for the HD gene mutation
    • For community controls: individuals with a major central nervous system disorder (e.g. stroke, Parkinson’s disease, Multiple Sclerosis, etc.)
    .

    Coordinator: Aadi Nalla aanalla@med.umich.edu; Chris Graves gravesch@med.umich.edu

  • University of Michigan Udall Center of Excellence for Parkinson’s Disease Research Updates

    DatePresenterAffiliationPresentation Title
    10/25/2023Per Borghammer, MD, PhD, DMScAarhus UniversityBrain-first vs body-first Parkinson’s disease – the idea, validation studies, and implications
    6/28/2023Bernardo Sabatini, MD, PhDHarvard UniversityBasal ganglia circuits for action selection and evaluation 
    5/31/2023Gordon MG Shepherd, MD, PhDNorthwestern UniversityCircuit organization of mouse motor cortex 
    3/29/2023Sam Crowley, PhD


    Alexander Johnson, PhD

    James Brissenden, PhD     		VA Ann Arbor Health Systems / Michigan Medicine

    U-M Department of Neurology

    U-M Department of Psychology     		The Basal Forebrain, Acetylcholine, and Cognition in Parkinson’s Disease

    Electrophysiological Signatures of a Basal Forebrain – Corticopetal System

    Restoration of vigor-motivation couplig in Parkinso’s disease requires both the short and long duration response to L-Dopa
    2/22/2023Honglei Chen, MD, PhDMSU Dept of Epidemiology and BiostatisticsResearch on environmental risk factors of Parkinson’s disease – challenges and strategies
    1/25/2023Simon Lewis, MBBCh, BSc, FRCP, FRACP, MDUniversity of SydneyParkinson’s and Phrenology for the 21st Century
    11/30/2022Christian Burgess, PhDU-M Department of Molecular & Integrative PhysiologyStriatal dopamine dynamics during skilled motor learning
    10/26/2022Yolanda Smith, PhDEmory UniversityPathophysiology of Thalamocortical and Corticofugal Systems in Parkinsonism
    9/28/2022Nicole Calakos, MD, PhDDuke UniversityNew roles for protein synthesis by the ISR in cholinergic modulation and movement disorders
    6/29/2022Michael Vesia, PhDU-M KinesiologyMeasuring and manipulating brain circuits for goal-directed movements with multi-focal transcranial magnetic stimulation
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